Age-related reduction of extrastriatal dopamine D2 receptor measured by PET
Age-related reduction of extrastriatal dopamine D2 receptor measured by PET
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DOI：
10.1016/s0024-3205(01)01205-x
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发表时间：
2001-07-20
期刊：
影响因子：
6.1
通讯作者：
Tanada, S
中科院分区：
文献类型：
--
作者：
Inoue, M;Suhara, T;Tanada, S
尽管纹状体中多巴胺D-2受体的衰老作用已被充分证明，但年龄对纹状体外多巴胺D-2受体的影响尚未得到充分研究。由于体外多巴胺D-2受体的密度很低，合适的配体有限。在这项研究中，我们使用[C-11]FLB 457来量化活体人脑的体外多巴胺D-2受体。27名年龄在21 ~ 82岁的健康男性受试者参加了正电子发射断层扫描研究。以小脑为参考区，建立参考组织模型，定量测定腹外[C-11]FLB 457的结合。Bmax /Kd对应的结合电位用于评估年龄相关的变化。我们发现，在所有测量的胃外区域，D-2受体结合的年龄相关减少。额叶皮质、颞叶皮质、顶叶皮质、枕叶皮质、海马和丘脑的D-2受体结合每10年减少13.8%、12.0%、13.4%、12.2%和4.8%。这些发现表明，作为正常衰老过程的一部分，大脑所有区域中D-2受体的数量都会下降。(C) 2001爱思唯尔科学公司版权所有。
Although the aging effect of dopamine D-2 receptor in the striatum is well-documented, the effect of age on the extrastriatal dopamine D-2 receptor has not been fully examined. Since the density of extrastriatal dopamine D-2 receptor is very low, suitable ligands are limited. In this study, we used [C-11]FLB 457 to quantify the extrastriatal dopamine D-2 receptor in the living human brain. Twenty-seven healthy male subjects aged from 21 to 82 years participated in the positron emission tomography study. Extrastriatal [C-11]FLB 457 binding was quantified with a reference tissue model using cerebellum as a reference region. Binding potentials corresponding to Bmax /Kd were used to evaluate age-related change. We found age-related decreases of D-2 receptor binding in all measured extrastriatal regions. The decrease of D-2 receptor binding was 13.8% per decade in frontal cortex, 12.0% in temporal cortex, 13.4% in parietal cortex, 12.4% in occipital cortex, 12.2% in hippocampus, and 4.8% in thalamus. These findings suggest that the amounts of D-2 receptor declines in all brain regions as part of the normal aging process. (C) 2001 Elsevier Science Inc. All rights reserved.