Prevention and Treatment of Hypertension Study (PATHS). Rationale and design.
Prevention and Treatment of Hypertension Study (PATHS). Rationale and design.
复制标题
高血压预防和治疗研究（PATHS）。
DOI：
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发表时间：
1994
影响因子：
3.2
通讯作者：
P. Allender
中科院分区：
文献类型：
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作者：
W. Cushman;J. Cutler;S. Bingham;T. Harford;E. Hanna;P. Dubbert;J. Collins;M. Dufour;D. Follman;P. Allender
在许多流行病学研究中，饮酒被认为是血压的重要相关因素，但很少有干预性研究来研究减少饮酒对血压的影响。因为这些研究通常包括很少的受试者并且持续时间短，所以国家心脏、肺和血液研究所（NHLBI）、国家酒精滥用和酒精中毒研究所（NIAAA）和退伍军人事务部（VA）合作研究计划已经启动了一项随机、对照、一项多中心试验，以确定非依赖性中度至重度饮酒者在6个月的适度饮酒后血压和左心室质量是否降低（平均每天饮酒三次或以上，但不依赖酒精），舒张压高于平均正常（80至89 mm Hg）和轻度高血压（90至99 mm Hg）水平，以及酒精摄入量的减少是否可以维持2年。符合条件的退伍军人被随机分配到七个临床站点的酒精减少干预组或对照观察组。预计样本量为580名参与者。通过使用回顾性日记（按时间顺序饮酒记录）的自我报告和在中心实验室分析的各种生化标志物（包括载脂蛋白、HDL胆固醇（和亚组分）和碳水化合物缺乏转铁蛋白）评估酒精摄入量。酒精干预技术是一种认知行为计划，其强化阶段包括3个月内的6次咨询会议。在基线和随机化后6个月获得超声心动图。这项试验对高血压的预防和治疗都有重要意义。
Alcohol consumption has been recognized as an important correlate of blood pressure in many epidemiologic studies, but few interventional studies have been conducted to examine the effect of a reduction in alcohol intake on blood pressure. Because these studies have usually included few subjects and been of short duration, the National Heart, Lung, and Blood Institute (NHLBI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the Veterans Affairs (VA) Cooperative Studies Program have initiated a randomized, controlled, multicenter trial to determine whether blood pressure and left ventricular mass are lowered over 6 months of alcohol moderation in non-dependent moderate to heavy drinkers (three or more drinks per day average but not alcohol dependent) with above-average normal (80 to 89 mm Hg) and mildly hypertensive (90 to 99 mm Hg) levels of diastolic blood pressure, and whether a reduction in alcohol intake can be maintained for 2 years. Eligible veterans are randomized to either an alcohol reduction intervention or a control observation group at seven clinical sites. The projected sample size is 580 participants. Alcohol intake is assessed by self-report using a retrospective diary (Chronological Drinking Record) and by various biochemical markers, including apolipoproteins, HDL cholesterol (and subfractions), and carbohydrate deficient transferrin, analyzed at a central laboratory. The alcohol intervention technique is a cognitive-behavioral program, the intensive phase of which consists of six counseling sessions over 3 months. Echocardiograms are obtained at baseline and 6 months after randomization. This trial has important implications for both the prevention and treatment of hypertension.