Viral fusion proteins: multiple regions contribute to membrane fusion.
Viral fusion proteins: multiple regions contribute to membrane fusion.
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DOI：
10.1016/s0005-2736(03)00170-6
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发表时间：
2003-07
期刊：
影响因子：
--
通讯作者：
S. Peisajovich;Y. Shai
中科院分区：
文献类型：
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作者：
S. Peisajovich;Y. Shai
近年来，病毒融合蛋白仅通过两个局部片段（即融合肽和跨膜结构域）与细胞和/或病毒膜相互作用的简单图片已经让位于更复杂的图片，其中来自病毒蛋白的多个区域与膜相互作用。事实上，已经假定N-末端七肽重复序列、前跨膜片段和来自远缘病毒（如正粘病毒、逆转录病毒、副粘病毒或黄病毒）的融合蛋白的其他内部区域在膜结合和/或去稳定中可能起作用。本文综述了迄今为止关于这些区域在病毒诱导的膜融合过程中的作用的实验证据和功能模型。
In recent years, the simple picture of a viral fusion protein interacting with the cell and/or viral membranes by means of only two localized segments (i.e. the fusion peptide and the transmembrane domain) has given way to a more complex picture in which multiple regions from the viral proteins interact with membranes. Indeed, possible roles in membrane binding and/or destabilization have been postulated for the N-terminal heptad repeats, pre-transmembrane segments, and other internal regions of fusion proteins from distant viruses (such as orthomyxo-, retro-, paramyxo-, or flaviviruses). This review focuses on the experimental evidence and functional models postulated so far about the role of these regions in the process of virus-induced membrane fusion.