Entorhinal cortex of the monkey: VII. Intrinsic connections
Entorhinal cortex of the monkey: VII. Intrinsic connections
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DOI：
10.1002/cne.21200
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发表时间：
2007-02-01
影响因子：
2.5
通讯作者：
Amaral, David G.
中科院分区：
文献类型：
--
作者：
Chrobak, James J.;Amaral, David G.
在食蟹猴中研究了内嗅皮层内内在连接的组织。顺行示踪剂（H-3-氨基酸，菜豆白细胞凝集素，生物素化葡聚糖胺，或荧光红宝石）注射到24只动物的内嗅皮层的深层或浅层。这些注射标记了广泛的内在投射，这些投射终止于内嗅皮层的所有层。标记通常是连续的，即，没有片状或柱状组织的证据。每次注射产生一个rostrocaudally定向带标记的纤维和终端，延长三分之一至一半的长度的内嗅皮层。标记纤维的更广泛分布更典型的尾侧注射部位。两者合计，预测确定至少两个mediolatilised带：一个横向带，包括字段Elr，Elc，和最外侧方面的字段Ec和Ecl和更广泛的，位于中间带，包括大部分的字段Er，Ei，Ec，和Ecl。我们获得了一些证据表明，领域Eo构成了第三个，非常中间放置带。标记纤维的喙尾组织和深层和浅层内的标记程度与注射的层流位置无关。这些数据表明，在猴子内嗅皮层的内在associatonal连接组织成单独的关联网络。我们的研究结果进行了讨论，参考层间连接在介导的新皮层和海马之间的生理相互作用的作用。
The organization of intrinsic connections within the entorhinal cortex was investigated in Macaca fascicularis monkeys. Anterograde tracers (H-3-amino acids, Phaseolus vulgaris-leucoagglutinin, biotinylated dextran amine, or Fluoro-Ruby) were injected into the deep or superficial layers of the entorhinal cortex in 24 animals. These injections labeled extensive intrinsic projections that terminated throughout all layers of the entorhinal cortex. Labeling was typically continuous i.e., there was no evidence of a patchy or columnar organization. Each injection produced a rostrocaudally oriented band of labeled fibers and terminals that extended for one-third to one-half of the length of the entorhinal cortex. The more extensive distributions of labeled fibers were more typical of caudally placed injection sites. Taken together, the projections identified at least two mediolaterally differentiated bands: a lateral band that encompasses fields Elr, Elc, and the most lateral aspect of fields Ec and Ecl and a wider, medially situated band that encompasses much of fields Er, Ei, Ec, and Ecl. We obtained some evidence that field Eo constitutes a third, very medially placed band. The rostrocaudal organization of labeled fibers and the extent of labeling within the deep and superficial layers were unrelated to the laminar position of the injection. These data suggest that intrinsic associatonal connections in the monkey entorhinal cortex are organized into separate associational networks. Our findings are discussed with reference to the role of interlaminar connections in mediating physiological interactions between the neocortex and the hippocampus.