Survival experience of 789 children with the acquired immunodeficiency syndrome.
Survival experience of 789 children with the acquired immunodeficiency syndrome.
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789例获得性免疫缺陷综合征儿童的生存经验。
DOI：
10.1097/00006454-199304000-00010
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Markson,LE
中科院分区：
文献类型：
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作者：
Turner,BJ;Denison,M;Eppes,SC;Houchens,R;Fanning,T;Markson,LE
为了确定生存的预测因素，我们研究了789名纽约医疗补助登记的儿童从1983年到1989年被诊断为获得性免疫缺陷综合征（AIDS）并随访到1990年的纵向病史。3种艾滋病定义疾病严重程度组的中位生存时间分别为66、48和9个月。在比例风险模型中，最严重组与最不严重组的死亡相对风险为3.33（95%置信区间，2.53，4.37），诊断时< 6个月的儿童与年龄较大的儿童的相对风险为1.81（95%置信区间，1.41，2.34）。我们通过使用4类严重程度指数来评估艾滋病定义诊断和诊断后3个月内的临床并发症，提高了预测死亡的能力（相对风险为5.27; 95%置信区间为3.16，最严重与最不严重的为8.78）。这些分析提供了新的临床严重性指标，并揭示，无论艾滋病定义诊断如何，< 6个月的艾滋病儿童预后不良。
To define predictors of survival we studied longitudinal histories of 789 New York State Medicaid-enrolled children diagnosed with acquired immunodeficiency syndrome (AIDS) from 1983 to 1989 and followed through 1990. Median survival times for 3 severity groups of AIDS-defining conditions were 66, 48 and 9 months. In a proportional hazards model, the relative risk of death for the most vs. least severe group was 3.33 (95% confidence interval, 2.53, 4.37) and the relative risk for children< 6 months old at diagnosis vs. older children was 1.81 (95% confidence interval, 1.41, 2.34). We increased our ability to predict death by using a 4-category severity index that assesses both the AIDS-defining diagnosis and clinical complications within 3 months of diagnosis (relative risk, 5.27; 95% confidence interval, 3.16, 8.78 for most vs. least severe). These analyses offer new clinical severity measures and reveal that, regardless of the AIDS-defining diagnosis, children with AIDS who are< 6 months old have a poor prognosis.