Individual variability in the diurnal intraocular pressure curve.
Individual variability in the diurnal intraocular pressure curve.
复制标题
每日眼压曲线的个体差异。
DOI：
10.1016/s0161-6420(93)31551-4
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发表时间：
1993
期刊：
影响因子：
13.7
通讯作者：
Zeimer,R
中科院分区：
文献类型：
--
作者：
Wilensky,JT;Gieser,DK;Dietsche,ML;Mori,MT;Zeimer,R
背景：降低眼内压（IOP）是大多数青光眼治疗的主要目标。然而，由于IOP在白天变化，在眼科医生的办公室进行的单次测量不一定提供的信息的峰值水平和波动的IPO.Methods：家庭眼压测量进行，以获得更多的信息的性质的昼夜IOP曲线和它们的变异性。176例开角型青光眼（OAG），55例高眼压症（OHT）和18名对照者测量他们的眼压每天5次，在家里连续4至8 days using a self-tonometer.Results：明确定义的昼夜眼压变化，观察到在所有三个组中的优势曲线与上午或中午的最大值。OHT（22%）和OAG（16%）患者的眼压曲线不稳定，无昼夜节律，而对照组则无此现象。个体双眼曲线之间的差异在OHT（33%）和OAG（36%）患者中很常见，但在对照组受试者中则不常见（6%）。最后，大多数的OHT（72%）和OAG（66%）的患者表现出不同的重复家庭眼压测量进行monthsapert.Conclusion：作者指出，这是很难依靠一只眼睛作为控制其他昼夜曲线模式。他们还表明，在不同访视时在诊室观察到的IOP变化通常可能是由于昼夜曲线类型的变化，而不是平均IOP的真实变化。在某些情况下，如果临床医生在做出患者管理决策时依赖（甚至部分依赖）IOP水平，则可能需要监测昼夜IOP。
Background:Reduction of intraocular pressure (IOP) is a primary goal of most glaucoma treatments. However, because the IOP varies during the day, single measurements performed in an ophthalmologist's office do not necessarily provide information on the peak level and fluctuation of the IOP.Methods:Home tonometry was performed to gain more information on the nature of the diurnal IOP curves and on their variability. One hundred seventy-six patients with open-angle glaucoma (OAG), 55 subjects with ocular hypertension (OHT), and 18 control individuals measured their IOP five times daily at home for 4 to 8 consecutive days using a self-tonometer.Results:Well-defined diurnal IOP variations were observed in all three groups with a predominance of curves with morning or mid-day maxima. Erratic IOP curves without a diurnal rhythm were present in OHT (22%) and OAG (16%) patients but not in control subjects. Differences between the curves of the two eyes of an individual were frequent in OHT (33%) and OAG (36%) patients but not in control subjects (6%). Finally, the majority of OHT (72%) and OAG (66%) patients showed a difference in their diurnal curve patterns on repeat home tonometry performed months apart.Conclusion:The authors indicate that it is difficult to rely on one eye as a control for the other. They also indicate that changes in IOP observed in the office at different visits often may be due to a shift in the type of diurnal curve rather than to a true change in the mean IOP. Monitoring of the diurnal IOP may be necessary in some cases if the clinician relies, even partially, on the level of IOP when making a decision on patient management.