Body composition, eating disorder psychopathology, and psychological distress in anorexia nervosa: a longitudinal study
Body composition, eating disorder psychopathology, and psychological distress in anorexia nervosa: a longitudinal study
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DOI：
10.3945/ajcn.113.078816
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发表时间：
2014-04-01
影响因子：
7.1
通讯作者：
Dalle Grave, Riccardo
中科院分区：
文献类型：
--
作者：
El Ghoch, Marwan;Milanese, Chiara;Dalle Grave, Riccardo
背景资料：虽然先前已经在神经性厌食症（AN）中研究了体重立即恢复对身体组成和体脂分布的影响，但据我们所知，其对患有AN的女性进食障碍、精神病理学和心理困扰的影响先前尚未研究过。目的：我们评估了体重恢复前后的身体成分和脂肪量分布，并研究了体脂变化与体重恢复之间的任何关系。在专科住院部接受治疗的AN患者的模式及其饮食障碍和心理困扰特征。设计：采用双能X线吸收法测量50名女性成人AN患者体重完全恢复前后的身体成分[体重指数（BMI;单位kg/m2）>= 18.5]和100名年龄和治疗后BMI相匹配的健康对照受试者。通过进食障碍检查访谈和简明症状量表的总体严重程度指数（BSI-GSI）分别评估AN组体重恢复前后的进食障碍精神病理学和心理困扰。在体重完全恢复后，AN患者的躯干较高，（P < 0.001）、男性型（P < 0.001）和女性型（P < 0.001）脂肪量以及下臂（P < 0.001）和腿部（P = 0.001）脂肪量。在AN组中，身体成分变量与进食障碍精神病理学之间没有相关性，BSI-GSI变化的唯一显著预测因素是基线BSI-GSI评分。结论：AN患者体重的正常化与中心区域体脂的优先分布相关，然而，这似乎不会影响进食障碍精神病理学或心理困扰评分。
Background: Although the effect of immediate weight restoration on body composition and body fat distribution has previously been studied in anorexia nervosa (AN), its influence in women with AN on eating disorder psychopathology and psychological distress has not previously been investigated to our knowledge.Objectives: We assessed body composition and fat mass distribution before and after body weight restoration and investigated any relation between changes in body fat patterns of patients with AN treated in a specialist inpatient unit and their eating disorder and psychological distress features.Design: Body composition was measured by using dual-energy X-ray absorptiometry in 50 female, adult patients with AN before and after complete weight restoration [body mass index (BMI; in kg/m(2)) >= 18.5] and 100 healthy control subjects matched by age and posttreatment BMI of study group participants. Eating disorder psychopathology and psychological distress were assessed in the AN group before and after weight restoration by using the Eating Disorder Examination interview and the Global Severity Index of the Brief Symptom Inventory (BSI-GSI), respectively.Results: After the achievement of complete weight restoration, patients with AN had higher trunk (P < 0.001), android (P < 0.001), and gynoid (P < 0.001) fat masses and lower arm (P < 0.001) and leg (P = 0.001) fat masses with respect to control subjects. No relation was shown between body-composition variables and eating disorder psychopathology in the AN group, and the only significant predictor of change in BSI-GSI was the baseline BSI-GSI score. Conclusion: The normalization of body weight in patients with AN is associated with a preferential distribution of body fat in central regions, which does not, however, seem to influence either eating disorder psychopathology or psychological distress scores.