Validation and comparison of reference equations for the 6-min walk distance test
Validation and comparison of reference equations for the 6-min walk distance test
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DOI：
10.1183/09031936.00104507
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发表时间：
2008-03-01
影响因子：
24.3
通讯作者：
Celli, B. R.
中科院分区：
文献类型：
--
作者：
Cote, C. G.;Casanova, C.;Celli, B. R.
通过6分钟步行距离（6 MWD）测试测量的运动损伤困扰着许多慢性阻塞性肺疾病（COPD）患者，并且已知可预测死亡率。成人6分钟步行距离的参考方程已发表，但尚未得到验证。本作者前瞻性地随访了1，379名COPD患者55 +/- 30个月，并测试了基线6分钟步行距离（以米为单位）、6分钟步行距离功（kg.m（-1））的预测值以及根据两个参考方程的6分钟步行距离（以米为单位）占预测值的百分比。全因死亡率是验证结果。利用受试者工作特征曲线（ROC曲线）确定了每种试验的最佳阈值，得到的阈值为：6 MWD为350 m，25，000 kg（.）m（-1），两个参考方程的预测值分别为67%和54%。所有的测试模式在预测COPD死亡率方面是相似的，并且与6 MWD测试相关性良好。总之，所有的测试模式同样可以很好地预测慢性阻塞性肺疾病的死亡率。在6分钟步行距离测试中，
Exercise impairment as measured by the 6-min walk distance (6MWD) test afflicts many patients with chronic obstructive pulmonary disease (COPD) and is known to predict mortality. Reference equations for the 6MWD in adults have been published but not yet validated.The present authors prospectively followed 1,379 COPD patients for 55 +/- 30 months and tested the predictive value of the baseline 6MWD in metres, the 6MWD work (kg.m(-1)) and as a percentage of predicted values the 6MWD in meters according to two reference equations. All-cause mortality was the validating outcome. The best threshold values were identified for each of the tests using receiver operating characteristic (ROC) curves.The threshold values obtained were: 350 m for the 6MWD, 25,000 kg(.)m(-1) for the 6MWD work, and 67 and 54% predicted for the two reference equations. All modalities of the testing were similar at predicting COPD mortality and correlated well with the 6MWD test.In conclusion, all modalities of testing predict mortality in chronic obstructive pulmonary disease equally well. In the 6-min walk distance test, a value