INTERCONNECTIONS AND ORGANIZATION OF PALLIDAL AND SUBTHALAMIC NUCLEUS NEURONS IN THE MONKEY
INTERCONNECTIONS AND ORGANIZATION OF PALLIDAL AND SUBTHALAMIC NUCLEUS NEURONS IN THE MONKEY
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DOI：
10.1002/cne.901970404
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
KELLER, JT
中科院分区：
文献类型：
--
作者：
CARPENTER, MB;BATTON, RR;KELLER, JT
研究了丘脑底丘脑和苍白球底丘脑投影的地形组织，以评估丘脑底核（STN）和苍白球（GP）之间的互连。在一系列松鼠猴逆行和顺行轴浆运输技术中，用于探索这些相互联系。将小体积的辣根过氧化物酶（HRP）选择性注射到：内侧苍白球段（MPS）、外侧苍白球段的头侧部分（LPS，GP内侧髓质层的嘴侧）、LPS的中央部分（GP内侧髓质层的外侧）。酶逆行转运至 STN 细胞表明：核内侧和尾侧 1/3 的细胞主要投射到 MPS，核中 1/3 内侧部分的细胞主要投射到 LPS 的喙部，核喙部 2/3 中部的细胞投射到 LPS 的中央部分，其中最大的贡献来自核的喙部区域。 STN 中的细胞和 LPS 中的轴突末端之间似乎存在反向背腹地形关系，STN 背侧区域的细胞投射到 LPS 的腹侧区域，而 STN 腹侧区域的细胞投射到 LPS 的背侧区域。由于 STN 规模较小，MPS 之间无法建立类似的关系。 STN 外侧三分之一的细胞不将末端投射到 MPS 或 LPS 的吻端或中央部分。 STN 外侧三分之一的细胞投射到 LPS 的尾部（GP 内侧髓质层的尾部）。桥脚核中的少量细胞投射到 MPS。苍白球底丘脑投射是根据将[3H]氨基酸注射到MPS、LPS和GP的两个部分的放射自显影来确定的。 MPS 中细胞的选择性标记不会导致同位素转运至 STN 的任何部分。 LPS 吻侧分裂中的细胞标记导致同位素转运至：STN 吻侧部分的内侧 2/3 和细胞核中三分之一的中央区域。 LPS 中央部分的细胞将纤维投射到 STN 的外侧三分之一处，贯穿其大部分的头尾范围。尽管 STN 是一个相对较小的核，但相对于 GP，它似乎被组织成传入部分和传出部分。丘脑下苍白肌纤维主要起源于 STN 的内侧 2/3，并按地形组织； STN 内特定且独立位置的细胞投射到 MPS 或 LPS 内界限清楚的终端。 STN 神经元的主要轴突侧支显然不供应两个苍白球节段，尽管不能排除这种可能性。投射到 MPS 的丘脑底神经元来自核内侧和尾部的细胞，这些细胞不接收来自 GP 或大脑皮层任何部分的投射。来自 LPS 的喙部和中央部分的苍白球底丘脑投射终止于 STN 内的独特位点。这些终止区域与丘脑下苍白球投射区域的比较表明，STN 和 LPS 之间的直接相互连接一定是部分的。如果 STN 和 GP 的 2 个主要部分之间存在功能性相互连接，则这些连接不是点对点的，并且必须涉及局部中间神经元。
The topographic organization of subthalamopallidal and pallidosubthalamic projections was studied to evaluate interconnections between the subthalamic nucleus (STN) and the globus pallidus (GP). In a series of squirrel monkeys retrograde and anterograde axoplasmic transport technics were used to explore these interconnections. Small volumes of horseradish peroxidase (HRP) were injected selectively into: the medial pallidal segment (MPS), the rostral division of the lateral pallidal segment (LPS, rostral to the medial medullary lamina of GP) the central division of the LPS (lateral to the medial medullary lamina of GP). Retrograde transport of the enzyme to cells in the STN indicated that: cells in the medial and caudal third of the nucleus project predominantly to the MPS, cells in medial portions of the middle third of the nucleus project predominantly to the rostral division of the LPS and cells in central portions of the rostral 2/3 of the nucleus project to the central division of the LPS, with the largest contribution derived from rostral regions of the nucleus. An inverse dorsoventral topographical relationship appears to exist between cells in the STN and axonal terminations in the LPS, in that cells in dorsal regions of the STN project to ventral regions of the LPS, while cells in ventral regions of the STN project to dorsal regions of the LPS. No similar relationship could be established between the STN and the MPS because of its smaller size. Cells in the lateral third of the STN do not project terminals to the MPS or the rostral or central divisions of the LPS. Cells in the lateral third of the STN project to the caudal division (caudal to the medial medullary lamina of the GP) of the LPS. A small number of cells in the pedunculopontine nucleus project to the MPS. Pallidosubthalamic projections were determined from autoradiographs based upon injections of [3H] amino acids into the MPS, the LPS and both segments of the GP. Selective labeling of cells in the MPS resulted in no transport of isotope to any part of the STN. Labeling of cells in the rostral division of the LPS resulted in transport of isotope to: the medial 2/3 of the rostral part of the STN and the central region of the middle third of the nucleus. Cells in the central division of the LPS projected fibers to the lateral third of the STN throughout most of its rostrocaudal extent. Even though the STN is a relatively small nucleus, it appears organized into afferent and efferent portions with respect to the GP. Subthalamopallidal fibers originate mainly from the medial 2/3 of the STN and are topographically organized; cells in specific and separate locations within the STN project to well-circumscribed terminations within either the MPS or the LPS. Major axonal collaterals of STN neurons apparently do not supply both pallidal segments, although this possibility cannot be excluded. Subthalamic neurons projecting to the MPS arise from cells in medial and caudal parts of the nucleus that do not receive projections from any part of the GP or from the cerebral cortex. Pallidosubthalamic projections derived from the rostral and central divisions of the LPS terminate in distinctive loci within the STN. Comparisons of these regions of termination with those that give rise to subthalamopallidal projections suggest that direct reciprocal connections between the STN and the LPS must be partial. If functional reciprocal connections exist between STN and the 2 major segments of the GP, these are not on a point for point basis and local interneurons must be involved.