The neural code of reward anticipation in human orbitofrontal cortex
The neural code of reward anticipation in human orbitofrontal cortex
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DOI：
10.1073/pnas.0912838107
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发表时间：
2010-03-30
影响因子：
11.1
通讯作者：
Haynes, John-Dylan
中科院分区：
文献类型：
--
作者：
Kahnt, Thorsten;Heinzle, Jakob;Haynes, John-Dylan
在可供选择的行为选项中进行最佳选择，需要对其可能的结果进行精确的预期表示。一个根本的问题是，这样的预期结果是如何在大脑中呈现的。在眼眶额叶皮质(OFC)的单个细胞水平上的奖励编码遵循一种比使用人类功能磁共振(FMRI)的研究更不同的编码方案。结合多变量模式分类和fMRI，我们证明了在OFC中可以从分布的fMRI模式中解码感官线索的奖励值。这种分布式表示与动物电生理学之前的报告相一致，这些报告表明，奖励是由不同的神经群体以相反的编码方案编码的。重要的是，在预期过程中代表特定价值的fMRI模式与在接受奖励过程中出现的模式相似。此外，我们还表明，这种编码相似性的程度与受试者使用价值信息来指导行为的能力有关。这些发现缩小了人类和动物的奖励编码之间的差距，并证实了OFC中的价值表征与预期或实际收到的奖励无关的概念。
An optimal choice among alternative behavioral options requires precise anticipatory representations of their possible outcomes. A fundamental question is how such anticipated outcomes are represented in the brain. Reward coding at the level of single cells in the orbitofrontal cortex (OFC) follows a more heterogeneous coding scheme than suggested by studies using functional MRI (fMRI) in humans. Using a combination of multivariate pattern classification and fMRI we show that the reward value of sensory cues can be decoded from distributed fMRI patterns in the OFC. This distributed representation is compatible with previous reports from animal electrophysiology that show that reward is encoded by different neural populations with opposing coding schemes. Importantly, the fMRI patterns representing specific values during anticipation are similar to those that emerge during the receipt of reward. Furthermore, we show that the degree of this coding similarity is related to subjects' ability to use value information to guide behavior. These findings narrow the gap between reward coding in humans and animals and corroborate the notion that value representations in OFC are independent of whether reward is anticipated or actually received.