High-Resolution pQCT Analysis at the Distal Radius and Tibia Discriminates Patients With Recent Wrist and Femoral Neck Fractures
High-Resolution pQCT Analysis at the Distal Radius and Tibia Discriminates Patients With Recent Wrist and Femoral Neck Fractures
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DOI：
10.1359/jbmr.080704
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发表时间：
2008-11-01
影响因子：
6.2
通讯作者：
Alexandre, Christian
中科院分区：
文献类型：
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作者：
Vico, Laurence;Zouch, Mohamed;Alexandre, Christian
我们使用3D高分辨率外周体内QCT（HR-pOCT）描述了两个原始骨质疏松症人群的脆性骨状态。绝经后妇女（C，对照组，n = 54）： WF，手腕。采用HR-pQCT对50例HF髋和62例近期骨折患者进行腰椎和髋部DXA面积骨密度（aBMD）、松质和皮质体积骨密度（vBMD）以及胫骨和桡骨的显微结构和几何参数进行分析。主成分分析（PCA）允许提取最能代表骨骼变量的因素。两组间比较采用协方差分析（ANCOVA）。PCA提取了两个因子（占整个变异性的80%）：在半径处，第一个因子是小梁参数的组合，第二个因子是皮质参数的组合。在胫骨处，我们发现了相反的情况。股骨颈aBMD在WF组（8.6%）和HF组（18%）下降（腰椎无差异）。WF显示桡骨小梁vBMD和数量减少20%。桡骨皮质vBMD和厚度分别下降6%和14%。在胫骨。只有皮质间室受到影响，骨面积、厚度和截面模量减少20%，vBMD减少6%。HF表现出与WF相同的桡骨小梁改变，但桡骨皮质参数的影响比WF更严重，骨面积减少（25%），厚度减少（28.5%）。和vBMD（11%）。胫骨骨小梁vBMD和数量分别下降26%和17.5%。胫骨皮质骨面积、厚度和截面模量下降了约30%，而vBMD下降了13%。胫骨的几何参数在健康和骨折患者之间以及手腕和髋部骨折患者之间显示出最大的差异。
We depict a fragility bone state in two primitive osteoporosis populations using 3D high-resolution peripheral in vivo QCT(HR-pOCT). Postmenopausal women (C, controls, n = 54: WF, wrist. n = 50: HF hip, n = 62 recent fractured patients) were analyzed for lumbar and hip DXA areal BMD (aBMD), cancellous and cortical volumetric BMD (vBMD), and microstructural and geometric parameters on tibia and radius by HR-pQCT. Principal component analysis (PCA) allowed extracting factors that best represent bone variables. Comparison between (groups was Made by analysis of covariance (ANCOVA). Two factors (>80%) of the entire variability) are extracted by PCA: at the radius, the first is a combination of trabecular parameters and the second of cortical parameters. At the tibia, we found the reverse. Femoral neck aBMD is decreased in WF (8.6%) and in HF (18%) groups (no lumbar difference). WF showed a similar to 20% reduction in radius trabecular vBMD and number. Radius cortical vBMD and thickness decrease by 6% and 14%, respectively. At the tibia. only the cortical compartment is affected, with similar to 20% reduction in bone area, thickness, and section modulus and 6% reduction in vBMD. HF showed same radius trabecular alterations than WF but radius cortical parameters are more severely, affected than WF with reduced bone area (25%), thickness (28.5%). and vBMD (11%). At the tibia, trabecular vBMD and number decrease by 26% and 17.5%, respectively. Tibia cortical hone area, thickness, and section Modulus showed a >30% decrease, whereas vBMD reduction reached 13%. Geometry parameters at the tibia displayed the greatest differences between healthy and fractured patients and between Wrist and hip fractures.