Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis
复制标题
DOI：
10.1016/s0304-3835(99)00257-8
复制
发表时间：
1999-12-01
期刊：
影响因子：
9.7
通讯作者：
Yamasaki, K
中科院分区：
文献类型：
--
作者：
Konoshima, T;Takasaki, M;Yamasaki, K
在我们继续从天然资源中寻找新的癌症化学预防剂的过程中，筛选出了几种人参植物。结果表明，从越南人参的根茎和根中分离得到了一种有效成分majono苷- r2 （MR2）。在以n -亚硝基二乙胺（DEN）为引发剂、苯巴比妥（PB）为启动子的小鼠肝肿瘤两阶段癌变实验中，MR2显示出了较强的抗肿瘤促进活性。此外，MR2对一氧化氮（NO）供体/12- o-十四烷酚-13-乙酸酯（TPA）或过氧亚硝酸盐/TPA诱导的小鼠皮肤两期癌变试验均有显著的抑制作用。1999爱思唯尔科学爱尔兰有限公司版权所有。
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Panax plants were screened. Consequently, the ocotillol-type saponin, majonoside-R2 (MR2), was obtained from the rhizome and root of Panax vietnamensis (Vietnamese ginseng) as an active constituent. MR2 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. Further, MR2 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin induced by nitric oxide (NO) donor/12-O-tetradecanoylphorbol-13-acetate (TPA) or peroxynitrite/TPA. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.