INHIBITION OF GROWTH OF CANDIDA-ALBICANS BY IRON-UNSATURATED LACTOFERRIN - RELATION OF HOST-DEFENSE MECHANISMS IN CHRONIC MUCOCUTANEOUS CANDIDIASIS
INHIBITION OF GROWTH OF CANDIDA-ALBICANS BY IRON-UNSATURATED LACTOFERRIN - RELATION OF HOST-DEFENSE MECHANISMS IN CHRONIC MUCOCUTANEOUS CANDIDIASIS
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DOI：
10.1093/infdis/124.6.539
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发表时间：
1971-01-01
影响因子：
6.4
通讯作者：
SCHADE, AL
中科院分区：
文献类型：
--
作者：
KIRKPATRICK, CH;GREEN, I;SCHADE, AL
由于血清和外部分泌物中的铁结合蛋白抑制某些微生物的生长，因此确定了乳铁蛋白对白色念珠菌生长的影响。铁不饱和蛋白明显损害酵母的复制，当乳铁蛋白饱和时，其生长抑制特性丧失。测定了慢性粘膜皮肤念珠菌病患者腮腺液和白细胞中乳铁蛋白的含量，并与正常人进行了比较。通过免疫荧光，乳铁蛋白定位于带型和成熟多形核中性粒细胞的细胞核中。患者和对照组白细胞中乳铁蛋白的分布没有差异，两组腮腺液中乳铁蛋白的平均浓度也没有差异。
Since iron-binding proteins in serum and external secretions inhibit growth of certain microorganisms, the effect of lactoferrin on growth ofCandida albicanswas determined. The iron-unsaturated protein markedly impaired replication of the yeast, and the growth-inhibitory property was lost when lactoferrin was saturated with iron. The content of lactoferrin in parotid fluids and leukocytes from patients with chronic mucocutaneous candidiasis was measured and compared to that of normal subjects. By immunofluorescence, lactoferrin was localized in the nuclei of band forms and mature polymorphonuclear neutrophiles. There were no differences in the distribution of lactoferrin in leukocytes from patients or controls, and the mean concentrations of lactoferrin in parotid fluids from the two groups were not different.