Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex
Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex
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DOI：
10.1016/s0925-4773(97)00177-9
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发表时间：
1998-01-01
影响因子：
2.6
通讯作者：
Schaller, HC
中科院分区：
文献类型：
--
作者：
Hermans-Borgmeyer, I;Hampe, W;Schaller, HC
最近，从人、兔和鸡中发现了一种具有独特结构域组合的新型跨膜蛋白。这种蛋白质具有低密度脂蛋白受体家族的特征，并与从水螅中分离的神经肽头激活剂的受体具有同源性。为了研究这种不寻常的新受体的表达的时间和空间模式，我们分离出了一种小鼠同源物，并根据其人类对应物，将其命名为mSorLA。北方印迹分析显示，mSorLA转录本在成年大脑中丰度最高，在各种其他器官中的水平较低，并在胚胎发育期间表达。原位杂交显示主要定位于皮质、海马和小脑的神经元。在胚胎发育过程中，mSorLA在大脑皮层中显示出独特的表达模式，其中神经元亚群在最终分化前被标记。在中枢神经系统外的形态发生活跃的区域也检测到mSorLA的转录本。(C)1998爱思唯尔科学爱尔兰有限公司
Recently, a new type of transmembrane protein with a unique combination of protein domains was characterized from human, rabbit and chicken. This protein exhibits features of the low-density lipoprotein receptor family and shows homology to the receptor of the neuropeptide head activator isolated from hydra. To study the temporal and spatial pattern of expression of this unusual new receptor we have isolated a murine homolog and, in accordance with its human counterpart, named it mSorLA. Northern blot analysis revealed the highest abundance of mSorLA transcripts in the adult brain, lower levels in a variety of other organs and expression during embryogenesis. In situ hybridization showed predominant localization in neurons of the cortex, the hippocampus and the cerebellum. During embryonic development mSorLA displayed a unique pattern of expression in the cerebral cortex, where a subpopulation of neurons was labeled before final differentiation. Transcripts of mSorLA were also detected outside the central nervous system in regions active in morphogenesis. (C) 1998 Elsevier Science Ireland Ltd.