Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network
Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network
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DOI：
10.1128/jcm.39.7.2565-2571.2001
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发表时间：
2001-07-01
影响因子：
9.4
通讯作者：
Klugman, KP
中科院分区：
文献类型：
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作者：
McGee, L;McDougal, L;Klugman, KP
由青霉素耐药和多重耐药肺炎球菌引起的疾病的出现已成为全球关注的问题，因此有必要确定此类菌株的流行病学传播情况。肺炎球菌分子流行病学网络于 1997 年在国际微生物学会联盟的支持下建立，旨在对耐药肺炎球菌克隆进行表征、标准化、命名和分类。在此，我们描述了导致全球抗菌素耐药性增加的 16 种肺炎球菌克隆的命名法。介绍了使用分子分型程序（脉冲场凝胶电泳、BOX-PCR 和多位点序列分型）识别这些克隆的指南，以及 16 个克隆的青霉素结合谱和大环内酯类耐药决定因素。该网络可以作为科学家合作识别重要人类病原体克隆的原型，并作为其他网络开发的模型。
The emergence of disease caused by penicillin-resistant and multidrug-resistant pneumococci has become a global concern, necessitating the identification of the epidemiological spread of such strains. The Pneumococcal Molecular Epidemiology Network was established in 1997 under the auspices of the International Union of Microbiological Societies with the aim of characterizing, standardizing, naming, and classifying antimicrobial agent-resistant pneumococcal clones. Here we describe the nomenclature for 16 pneumococcal clones that have contributed to the increase in antimicrobial resistance worldwide. Guidelines for the recognition of these clones using molecular typing procedures (pulsed-field gel electrophoresis, BOX-PCR, and multilocus sequence typing.) are presented, as are the penicillin-binding profiles and macrolide resistance determinants for the 16 clones. This network can serve as a prototype for the collaboration of scientists in identifying clones of important human pathogens and as a model for the development of other networks.