EFFERENT PROJECTIONS OF THE INFRALIMBIC (AREA 25) REGION OF THE MEDIAL PREFRONTAL CORTEX IN THE RAT - AN ANTEROGRADE TRACER PHA-L STUDY
EFFERENT PROJECTIONS OF THE INFRALIMBIC (AREA 25) REGION OF THE MEDIAL PREFRONTAL CORTEX IN THE RAT - AN ANTEROGRADE TRACER PHA-L STUDY
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DOI：
10.1016/0006-8993(91)91677-s
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发表时间：
1991-12-06
期刊：
影响因子：
2.9
通讯作者：
CHIBA, T
中科院分区：
文献类型：
--
作者：
TAKAGISHI, M;CHIBA, T
用菜豆亮氨酸凝集素顺行转运法(PHA-L)观察了大鼠内侧前额叶皮质边缘下区(IL)的传出投射。IL的主要靶点包括无颗粒岛叶皮质、嗅结节、虹膜周围皮质、整个杏仁复合体、尾壳核、伏隔核、终纹床核、中线核、视前外侧核、室旁核、乳头上核、乳头体内侧核、下丘脑背侧和后部、腹侧被盖区、中央灰质、脚间核、中缝背侧、臂旁外侧核和蓝斑。以前未见报道的IL投射到嗅前核、梨状皮质、下丘脑前区和下丘脑外侧前核。标记终末密度以无颗粒岛叶皮质、嗅结节、丘脑内侧核内侧支、下丘脑背侧区和杏仁中央核外侧支最高。一些生理学和药理学研究表明，IL起着“内脏运动”皮质的作用，参与自主神经与行为和情感事件的整合。本研究是对支持这一概念的IL传出投射的首次全面研究。
The efferent projections of the infralimbic region (IL) of the medial prefrontal cortex of the rat were examined by using the anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L). Major targets of the IL were found to include the agranular insular cortex, olfactory tubercle, perirhinal cortex, the whole amygdaloid complex, caudate putamen, accumbens nucleus, bed nucleus of the stria terminalis, midline thamalic nuclei, the lateral preoptic nucleus, paraventricular nucleus, supramammillary nucleus, medialmammillary nucleus, dorsal and posterior areas of the hypothalamus, ventral tegmental area, central gray, interpeduncular nucleus, dorsal raphe, lateral parabrachial nucleus and locus coeruleus. Previously unreported projections of the IL to the anterior olfactory nucleus, piriform cortex, anterior hypothalamic area and lateroanterior hypothalamic nucleus were observed. The density of labeled terminals was especially high in the agranular insular cortex, olfactory tubercle, medial division of the mediodorsal nucleus of the thalamus, dorsal hypothalamic area and the lateral division of the central amygdaloid nucleus. Several physiological and pharmacological studies have suggested that the IL functions as the 'visceral motor' cortex, involved in autonomic integration with behavioral and emotional events. The present investigation is the first comprehensive study of the IL efferent projections to support this concept.