Vaccines against Campylobacter jejuni.
Vaccines against Campylobacter jejuni.
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空肠弯曲菌疫苗。
DOI：
10.1086/513791
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Daniel A. Scott
中科院分区：
文献类型：
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作者：
Daniel A. Scott
空肠弯曲菌是世界范围内腹泻的最常见原因之一。弯曲杆菌感染的胃肠道表现从水样腹泻到严重的痢疾不等。弯曲杆菌感染也与反应性关节炎和格林-巴利综合征的感染后后遗症有关。来自流行病学和志愿者研究的证据表明，开发预防胃肠道疾病和限制定植的疫苗是可能的。开发减毒活疫苗或亚单位疫苗的努力分别受到弯曲杆菌致病机理的有限知识和缺乏保守保护性抗原的限制。一种口服灭活的全细胞疫苗已在动物模型中被证明是安全有效的，目前正在I期志愿者研究中进行测试。
Campylobacter jejuni is one of the most common causes of diarrhea worldwide. The gastrointestinal manifestations of Campylobacter infection range from watery diarrhea to severe dysentery. Campylobacter infection has also been linked to the postinfectious sequelae of reactive arthritis and Guillain-Barré syndrome. Evidence from epidemiologic and volunteer studies suggests that development of a vaccine to prevent gastrointestinal disease and limit colonization is possible. Efforts to develop live attenuated or subunit vaccines are limited by the finite knowledge of Campylobacter pathogenesis and lack of a conserved protective antigen, respectively. An oral killed, whole-cell vaccine has been shown to be safe and effective in animal models and is currently being tested in phase I volunteer studies.