Noncontraceptive estrogens and nonfatal myocardial infarction.
Noncontraceptive estrogens and nonfatal myocardial infarction.
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非避孕雌激素和非致命性心肌梗塞。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
K. Rothman
中科院分区：
文献类型：
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作者：
H. Jick;B. Dinan;K. Rothman
我们收集了107例年龄小于46岁的急性心肌梗死患者的资料。在这个系列中，有17名年龄在39到45岁之间的妇女，她们在其他方面都很健康，有过自然绝经、子宫切除术、输卵管结扎术或其配偶有过输精管切除术。其中，9人（53%）在入院前服用非避孕雌激素。在34名对照组妇女中，有4名（12%）服用雌激素。使用雌激素者与不使用雌激素者相比，相对风险估计值为7.5，90%置信限为2.4和24。17 ml受试者中除1人外均吸烟。虽然这种疾病在大多数健康的年轻女性中很少见，但吸烟和服用雌激素的38岁以上女性的风险似乎很大。
We obtained information on 107 women younger than 46 years discharged from a hospital with a diagnosis of acute myocardial infarction. In the series there were 17 women aged 39 to 45 years who were otherwise apparently healthy and had had a natural menopause, hysterectomy, or tubal ligation or whose spouse had had a vasectomy. Among them, nine (53%) were taking noncontraceptive estrogens just prior to admission. Among 34 control women, four (12%) were taking estrogens. The relative risk estimate, comparing estrogen users with nonusers, is 7.5, with 90% confidence limits of 2.4 and 24. All but one of the 17 ml subjects were cigarette smokers. While this illness is rare in most healthy young women, the risk in women older than about 38 years who both smoke and take estrogens appears to be substantial.