The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy
The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy
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DOI：
10.1016/s0165-2427(01)00348-8
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发表时间：
2001-09-20
影响因子：
1.8
通讯作者：
Hillier, A
中科院分区：
文献类型：
--
作者：
Griffin, CE;Hillier, A
过敏原特异性免疫疗法（ASIT）多年来一直用于治疗患有特应性皮炎（AD）的狗和患有特应性疾病的人类。 ASIT 对于患有呼吸道特应性疾病和螫刺昆虫过敏的人类的疗效已得到充分证明，但其对于 AD 患者的有效性似乎更具争议性。尽管来自随机对照试验的证据不足，但多项开放研究和大量临床观察表明 ASIT 可以有效控制患有 AD 的狗的临床症状。由于缺乏对照试验的证据，ASIT 的真正功效以及过敏原剂量和注射频率的最佳方案目前尚不清楚。尽管如此，过敏原特异性免疫疗法可能被纳入犬 AD 的治疗中，因为与其他形式的疗法相比，其具有潜在的优点和有限的缺点。然而，没有证据表明偏好任何特定的治疗方案。本文讨论了与 ASIT 对 AD 犬疗效相关的历史、临床和免疫学特征的预测价值。然后对不良反应以及接受 ASIT 的患者的监测要求进行审查和详细说明。最后，本综述强调了 ASIT 需要进一步研究和对照研究的方面。 (C) 2001 年由 Elsevier Science B.V. 出版
Allergen-specific immunotherapy (ASIT) has been used for years to treat dogs with atopic dermatitis (AD) and humans with atopic diseases. The efficacy of ASIT has been well documented for humans with respiratory atopic diseases and stinging insect allergy, but its effectiveness seems more controversial for patients with AD. In spite of insufficient evidence derived from randomized controlled trials, multiple open studies and a large body of clinical observations suggest that ASIT is effective in controlling the clinical signs of dogs with AD. As a result of the scarcity of evidence from controlled trials, the true efficacy of ASIT, and the optimal protocols for allergen dose and frequency of injection are currently unknown. Allergen-specific immunotherapy nevertheless may be included in the treatment of canine AD because of its potential advantages and limited disadvantages compared to other forms of therapy. There is no evidence, however, for the preference of any specific treatment protocol. The predictive value of historical, clinical and immunologic features related to the efficacy of ASIT in dogs with AD are discussed in this paper. Adverse reactions, and the requirements for monitoring of patients receiving ASIT, then are reviewed and detailed. Finally, this review highlights aspects of ASIT where further research and controlled studies are needed. (C) 2001 Published by Elsevier Science B.V.