ANTERIOR TEMPORAL LANGUAGE AREAS IN PATIENTS WITH EARLY-ONSET OF TEMPORAL-LOBE EPILEPSY
ANTERIOR TEMPORAL LANGUAGE AREAS IN PATIENTS WITH EARLY-ONSET OF TEMPORAL-LOBE EPILEPSY
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DOI：
10.1002/ana.410340517
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发表时间：
1993-11-01
影响因子：
11.2
通讯作者：
DOGALI, M
中科院分区：
文献类型：
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作者：
DEVINSKY, O;PERRINE, K;DOGALI, M
连续18例接受优势颞叶切除术的患者接受术前皮层刺激进行语言定位。在前颞叶（距颞极4.5 cm）刺激时有命名障碍的患者比没有这种障碍的患者癫痫发作更早（5.8岁比12.9岁; p < 0.04）。阅读错误也有类似的趋势（6.3年vs 12.4年; p < 0.052）。切除总是保留至少1厘米前的任何语言区。术后神经心理学测试在有和没有前语言表征的患者之间没有显著差异。优势颞叶癫痫灶的早期发作导致语言区的分布更广泛或不典型。癫痫手术中应考虑个体差异，以减少术后语言障碍。
Eighteen consecutive patients undergoing dominant temporal lobectomy underwent preoperative cortical stimulation for language localization. Patients with naming deficits on anterior (4.5 cm from the temporal pole) temporal lobe stimulation had earlier seizure onset vs those without such deficits (5.8 yr vs 12.9 yr; p < 0.04). There was a similar trend for reading errors (6.3 yr vs 12.4 yr; p < 0.052). Resections always spared at least 1 cm anterior to any language area. There was no significant difference in postoperative neuropsychological tests between patients with and without anterior language representation. Early onset of dominant temporal lobe seizure foci leads to a more widespread or atypical distribution of language areas. Individual variability should be considered in epilepsy surgery to reduce postoperative language deficits.