Frequency of early and late‐onset dementias in a Japanese memory disorders clinic
Frequency of early and late‐onset dementias in a Japanese memory disorders clinic
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日本记忆障碍诊所中早发性和迟发性痴呆的发生频率
DOI：
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发表时间：
2005
影响因子：
5.1
通讯作者：
S. Kuroda
中科院分区：
文献类型：
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作者：
O. Yokota;Ken Sasaki;Y. Fujisawa;Jun Takahashi;S. Terada;T. Ishihara;H. Nakashima;Akihide Kugo;Toshie Ata;H. Ishizu;S. Kuroda
本研究的目的是比较日本记忆障碍诊所中早发性（年龄<65岁）和迟发性（年龄≥65岁）痴呆患者的诊断特征。 共有512个连续的记忆诊所的病人进行了评估，使用临床信息和检查结果。根据DSM-III-R进行痴呆诊断，根据标准诊断标准进行亚型诊断。共有464名患者符合痴呆症的标准。在晚发型患者（n = 430）中，阿尔茨海默病（AD）（48.1%）是痴呆的最常见原因，其次是AD伴脑血管疾病（CVD）（31.4%）、血管性痴呆（VaD）（9.1%）、路易体痴呆（DLB）（3.7%）、额颞叶变性（FTLD）（1.6%）和其他（5.8%）。 相反，在早发患者（n = 34）中，最常见的痴呆诊断是AD（38.2%），其次是VaD（23.5%）、FTLD（14.7%）、AD伴CVD（5.9%）、DLB（2.9%）和其他（17.6%）。 FTLD和VaD在早发组中明显更常见。除1例患者外，所有DLB和帕金森病痴呆患者均为迟发性。在我们的系列中，AD、VaD和DLB的相对频率与几个西方国家的流行病学结果一致;然而，FTLD的频率与先前在一些西方国家晚发型患者中出现高频率的结果不一致。
The aim of this study was to compare the diagnostic profiles of patients with early (age <65 years) and late (age ≥65 years) onset of dementia in a memory disorders clinic in Japan. A total of 512 consecutive memory clinic patients were evaluated using clinical information and results of examinations. Diagnosis of dementia was made according to DSM‐III‐R, and that of subtypes according to standard diagnostic criteria. A total of 464 patients met the criteria for dementia. Amongst late‐onset patients (n = 430), Alzheimer's disease (AD) (48.1%) was the most frequent cause of dementia, followed by AD with cerebrovascular disease (CVD) (31.4%), vascular dementia (VaD) (9.1%), dementia with Lewy bodies (DLB) (3.7%), frontotemporal lobar degeneration (FTLD) (1.6%), and others (5.8%). On the contrary, amongst early onset patients (n = 34), the most common dementia diagnosis was AD (38.2%), followed by VaD (23.5%), FTLD (14.7%), AD with CVD (5.9%), DLB (2.9%), and others (17.6%). FTLD and VaD were significantly more common in the early onset group. All patients, but one, with DLB and Parkinson's disease dementia were late‐onset. The relative frequencies of AD, VaD, and DLB in our series are consistent with epidemiologic findings in several Western countries; however, the frequency of FTLD is not consistent with the previous findings presenting high frequency in late‐onset patients in some Western countries.
影响因子：
9.9
作者：
R. Faber
通讯作者：
R. Faber