SURAMIN - A REVERSIBLE P2-PURINOCEPTOR ANTAGONIST IN THE MOUSE VASDEFERENS
SURAMIN - A REVERSIBLE P2-PURINOCEPTOR ANTAGONIST IN THE MOUSE VASDEFERENS
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DOI：
10.1111/j.1476-5381.1988.tb11427.x
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发表时间：
1988-02-01
影响因子：
7.3
通讯作者：
BLAKELEY, AGH
中科院分区：
文献类型：
--
作者：
DUNN, PM;BLAKELEY, AGH
测试了杀锥虫剂苏拉明作为小鼠输精管 P2 嘌呤受体的可能拮抗剂。在100μM的浓度下，苏拉明拮抗对α，β-亚甲基ATP的反应，而对卡巴胆碱和去甲肾上腺素的反应不受影响。这些结果表明苏拉明可能为开发 P2-嘌呤受体特异性拮抗剂提供一个起点。
The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 .mu.M, Suramin antagonized the response to .alpha.,.beta.-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists of P2-purinoceptors.