Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
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DOI：
10.1016/s1534-5807(03)00244-2
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发表时间：
2003-09-01
影响因子：
11.8
通讯作者：
Perrimon, N
中科院分区：
文献类型：
--
作者：
Agaisse, H;Petersen, UM;Perrimon, N
为了描述果蝇免疫应答中JAK/STAT信号的特征，我们已经确定totA是一个受JAK/STAT通路调控的基因，在脓毒性损伤应答中起作用。我们发现，败血性损伤会触发upd3的血细胞特异性表达，upd3是一种编码新型upd样细胞因子的基因，它是JAK/ stat依赖性激活totA在果蝇的哺乳动物肝脏脂肪体中的必要条件。此外，我们证明totA激活也需要NF-KB样的津津乐通路，这表明脂肪体细胞在免疫应答时整合了NF-KB和JAK/STAT信号通路的活性。这项研究表明，除了模式识别受体介导的nf - kb依赖性免疫反应外，果蝇还经历了一个复杂的全身反应，该反应是由血细胞中细胞因子的产生介导的，这一过程类似于哺乳动物的急性期反应。
To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury. We show that septic injury triggers the hemocyte-specific expression of upd3, a gene encoding a novel Upd-like cytokine that is necessary for the JAK/STAT-dependent activation of totA in the Drosophila counterpart of the mammalian liver, the fat body. In addition, we demonstrate that totA activation also requires the NF-KB-like Relish pathway, indicating that fat body cells integrate the activity of NF-KB and JAK/STAT signaling pathways upon immune response. This study reveals that, in addition to the pattern recognition receptor-mediated NF-KB-dependent immune response, Drosophila undergoes a complex systemic response that is mediated by the production of cytokines in blood cells, a process that is similar to the acute phase response in mammals.