Cognitive impairment in adults with good recovery after bacterial meningitis
Cognitive impairment in adults with good recovery after bacterial meningitis
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DOI：
10.1086/344229
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发表时间：
2002-10-01
影响因子：
6.4
通讯作者：
Vermeulen, M
中科院分区：
文献类型：
--
作者：
van de Beek, D;Schmand, B;Vermeulen, M
细菌性脑膜炎后没有神经系统后遗症的成年人应该不受限制地生活。对51名在肺炎球菌性或脑膜炎球菌性脑膜炎后恢复良好（定义为格拉斯哥结局量表评分5分）的前瞻性队列中的成人进行神经心理学结局评估。肺炎球菌脑膜炎后恢复良好的患者表现出认知缓慢（P = .001）。在这些患者中发现了27%的认知障碍。既往患有脑膜炎双球菌性脑膜炎的患者与对照组无显著差异。一般健康和生活质量问卷的评分显示脑膜炎患者的评分较低，这与认知减慢有关（R，-0.46至-0.38）。总之，肺炎球菌性脑膜炎存活的成年人有显著的神经心理异常风险，即使他们临床上恢复良好。
Adults without neurologic sequelae after bacterial meningitis are supposed to live without restrictions. Neuropsychological outcome was assessed in 51 adults from a prospective cohort with good recovery, defined as Glasgow Outcome Scale score 5, after pneumococcal or meningococcal meningitis. Patients who recovered well after pneumococcal meningitis showed cognitive slowness (P = .001). A cognitive disorder was found in 27% of these patients. Patients who previously had meningococcal meningitis were not significantly different from control subjects. Scores on general health and quality of life questionnaires revealed lower scores for patients with meningitis, which were related to cognitive slowing (R, -0.46 to -0.38). In conclusion, adults surviving pneumococcal meningitis were at significant risk of neuropsychological abnormalities, even if they were clinically well recovered.