Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus
Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus
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DOI：
10.1128/aac.46.2.558-560.2002
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发表时间：
2002-02-01
影响因子：
4.9
通讯作者：
Shimamura, T
中科院分区：
文献类型：
--
作者：
Hu, ZQ;Zhao, WH;Shimamura, T
碳青霉烯类和没食子儿茶素没食子酸酯（EGCg；茶儿茶素的主要成分）的组合显示出对24株耐甲氧西林金黄色葡萄球菌（MRSA）的有效协同作用。EGCg存在时亚胺培南的mic值分别为3.125、6.25、12.5和25马克杯/毫升，分别对8%、38%、46%和75%的MRSA分离株恢复到敏感断点（小于或等于4马克杯/毫升）。帕尼培南或美罗培南与EGCg联合使用也观察到类似的结果。因此，该组合可能值得进一步在体内对MRSA感染进行评估。
Combinations of carbapenems and epigallocatechin gallate (EGCg; a main constituent of tea catechins) showed potent synergy against 24 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). MICs of imipenem in the presence of EGCg at 3.125, 6.25, 12.5, and 25 mug/ml, were restored to the susceptible breakpoint (less than or equal to4 mug/ml) for 8, 38, 46, and 75% of the MRSA isolates, respectively. Similar results were also observed for combinations of panipenem or meropenem and EGCg. Therefore, the combinations may be worthy of further evaluation in vivo against MRSA infection.