Revised formulas for summarizing retinal vessel diameters
Revised formulas for summarizing retinal vessel diameters
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DOI：
10.1076/ceyr.27.3.143.16049
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发表时间：
2003-09-01
影响因子：
2
通讯作者：
Klein, BEK
中科院分区：
文献类型：
--
作者：
Knudtson, MD;Lee, KE;Klein, BEK
背景/目的。最近的研究结果表明，眼底照片视网膜血管口径的客观评估提供了有关微血管特征与大血管疾病的关联信息。由Parr（1-2）和Hubbard（3）引入的用于量化视网膜血管口径的当前方法并不独立于尺度，而是受血管数量的影响。为了改进这些方法，我们介绍了修订后的公式量化血管口径。使用44名无高血压和糖尿病的年轻人的视网膜血管测量来估计修订后的公式。两种方法之间的比较使用数字化照片从4926名参与者在基线检查的比弗坝眼科研究（BDES），一个正在进行的人口为基础的队列研究开始于1987年。使用半自动计算机软件测量个体小动脉和小静脉，并计算汇总测量值。Parr-Hubbard公式和修正公式之间的相关系数较高（Pearson相关系数范围为0.94至0.98）。随着使用Parr-Hubbard公式测量的血管数量的增加，小动脉和小静脉口径均显著增加（p < 0.001），这反过来影响了与平均动脉血压的关系。而修正后的公式不受测量血管数目的影响（p > 0.50）。我们描述了修订后的公式，总结眼底照片测量视网膜血管直径用于未来的研究和分析。修订后的公式与以前使用的Parr-Hubbard公式高度相关，但提供的优点是对观察到的血管数量的变化更鲁棒，独立于图像尺度，更容易实现。
Background/Purpose. Recent findings suggest that an objective assessment of retinal vessel caliber from fundus photographs provide information about the association of microvascular characteristics with macrovascular disease. Current methods used to quantify retinal vessel caliber, introduced by Parr(1-2) and Hubbard,(3) are not independent of scale and are affected by the number of vessels. To improve upon these methods we introduce revised formulas for quantifying vessel caliber.Methods. Revised formulas were estimated using retinal vessel measurements from 44 young adults free of hypertension and diabetes. Comparisons between the two methods were done using digitized photographs from 4926 participants at the baseline examination of the Beaver Dam Eye Study (BDES), an ongoing population-based cohort study initiated in 1987. Individual arterioles and venules were measured using semi-automated computer software from which summary measures were calculated.Results. Correlation coefficients between the Parr-Hubbard and revised formulas were high (Pearson correlation coefficients ranging from 0.94 to 0.98). Both arteriolar and venular caliber significantly increased with an increasing number of vessels measured using the Parr-Hubbard formulas (p < 0.001), which in turn affected the relationship to mean arterial blood pressure. To the contrary, the revised formulas were not affected by the number of measured vessels (p > 0.50).Conclusions. We describe revised formulas for summarizing retinal vessel diameters measured from fundus photographs to be used in future studies and analyses. The revised formulas correlate highly with the previously used Parr-Hubbard formulas, but offer the advantages of being more robust against variability in the number of vessels observed, being independent of image scale, and being easier to implement.