Sexual Dimorphisms in the Associations of BMI and Body Fat with Indices of Pubertal Development in Girls and Boys
Sexual Dimorphisms in the Associations of BMI and Body Fat with Indices of Pubertal Development in Girls and Boys
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DOI：
10.1210/jc.2014-1384
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发表时间：
2014-08-01
影响因子：
5.8
通讯作者：
Yanovski, Jack A.
中科院分区：
文献类型：
--
作者：
Crocker, Melissa K.;Stern, Elizabeth A.;Yanovski, Jack A.
内容：青春期发育的肥胖和伴随的胰岛素抵抗的影响是不完全eldericated.Objective：要确定如何肥胖和胰岛素抵抗的措施与青春期成熟的男孩和女孩。设置和设计：乳房和阴毛坦纳阶段和睾丸体积的测量法测定的体格检查在1066名儿童。通过经腹超声估计卵巢体积。在美国国立卫生研究院临床研究中心测量脂肪量、骨龄、空腹血清胰岛素和葡萄糖、总T、雌二醇、雌酮、硫酸脱氢表雄酮和雄烯二酮。方便样品;结果：Logistic回归分析显示，性别和肥胖对青春期发育的预测有显著的交互作用（P
Context: The effect of obesity and concomitant insulin resistance on pubertal development is incompletely elucidated.Objective: To determine how measures of adiposity and insulin resistance are associated with pubertal maturation in boys and girls.Setting and Design: Breast and pubic hair Tanner stage and testicular volume by orchidometry were determined by physical examination in 1066 children. Ovarian volume was estimated by trans-abdominal ultrasound. Fat mass, skeletal age, and fasting serum for insulin and glucose, total T, estradiol, estrone, dehydroepiandrosterone-sulfate, and androstenedione were measured at the National Institutes of Health Clinical Research Center. Convenience sample; 52% obese, 59% female.Results: Logistic regression identified a significant interaction between sex and obesity for prediction of pubertal development (P