Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin-6 to support B-cell development via p63/p73 transcription factors
Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin-6 to support B-cell development via p63/p73 transcription factors
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DOI：
10.1002/path.2266
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发表时间：
2008-01-01
影响因子：
7.3
通讯作者：
Sato, N.
中科院分区：
文献类型：
--
作者：
Koshiba, S.;Ichimiya, S.;Sato, N.
掌跖脓疱病（PPP）是一种自身免疫性疾病，其特征是由于异常的体液免疫反应导致手掌和/或脚底出现牛皮癣样红斑性病变。扁桃体切除术是治疗PPP的有效方法；然而，扁桃体如何参与PPP的病因尚不清楚。在这里，我们分析了手术切除的36例PPP的腭扁桃体，以及常见的复发性扁桃体炎（RT）作为对照。组织学检查显示，与RT患者相比，PPP患者扁桃体中更常观察到一种独特的病变，即淋巴滤泡被网状隐窝上皮细胞包围（p < 0.0001; PPP vs RT）。有趣的是，来自PPP扁桃体的原代培养的隐窝上皮细胞显示出明显的白细胞介素-6 （IL-6）的产生。此外，这些来自PPP扁桃体的上皮细胞在细胞核中表达p53相关的转录因子，这些转录因子被发现有助于上调IL-6基因的表达。这些发现表明，至少在一定程度上，PPP扁桃体在p53相关因素控制下的特化淋巴上皮共生可能与自身抗体异常产生的受损微环境的产生有关。版权所有(c) 2007大不列颠和爱尔兰病理学会。约翰·威利父子有限公司出版。
Palmoplantar pustulosis (PPP) is an autoimmune disease characterized by psoriasis-like erythematous lesions on palms and/or soles due to an abnormal humoral immune response. Tonsillectomy is effectively employed for the treatment of PPP; however, how tonsils are involved in the aetiology of PPP remains unclear. Here we analysed surgically resected palatine tonsils from 36 cases of PPP as well as usual recurrent tonsillitis (RT) as a control. Histological examination revealed that a unique lesion, with lymphoid follicles surrounded by reticular crypt epithelial cells, was more frequently observed in tonsils of patients with PPP than in those with RT (p < 0.0001; PPP vs RT). Interestingly, crypt epithelial cells in primary cultures derived from PPP tonsils showed marked production of interleukin-6 (IL-6). Moreover, these epithelial cells from PPP tonsils expressed p53-related transcription factors in their nuclei that were found to contribute to the up-regulation of IL-6 gene expression. These findings suggest that, at least in part, the specialized lymphoepithelial symbiosis of PPP tonsils, under the control of p53-related factors, may be relevant to the generation of the impaired micro-environment underlying the aberrant production of autoantibodies. Copyright (c) 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.