Comparison of Axial Lengths in Occludable Angle and Angle-Closure Glaucoma-The Bhaktapur Glaucoma Study
Comparison of Axial Lengths in Occludable Angle and Angle-Closure Glaucoma-The Bhaktapur Glaucoma Study
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DOI：
10.1097/opx.0b013e318205e320
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发表时间：
2011-01-01
影响因子：
1.4
通讯作者：
van Rens, Ger H. M. B.
中科院分区：
文献类型：
--
作者：
Thapa, Suman S.;Paudyal, Indira;van Rens, Ger H. M. B.
目的.比较正常、可闭角型和原发性闭角型青光眼（PACG）患者的前房深度（ACD）和眼轴长度。一项基于人群的青光眼患病率研究中共有3979名受试者接受了包括四镜房角镜检查在内的完整眼部检查。不能看到后小梁网> 270度的角度被认为是可闭塞的。当存在原发性房角闭合（眼睛有可闭合的房角、周边前粘连、眼内压升高、虹膜涡动、透镜混浊或小梁表面色素沉积过多）和视盘伴青光眼损伤时，考虑PACG。使用手持式超声生物测量仪测量受试者的ACD和轴长。测量了86例可闭角患者、17例PACG患者和685例正常人的ACD和眼轴长度。采用独立样本t检验、单因素方差分析、卡方检验和Logistic回归分析。可闭角型青光眼和闭角型青光眼组的平均年龄分别为59.64 ± 9.70岁和71.23 ± 8.5岁，显著高于正常受试者的平均年龄54.03 ± 10.90岁（p < 0.001）。在可闭角组中，ACD（2.55 +/- 0.69）与正常组（2.85 +/- 0.39）相比有显著差异（p < 0.001）。与正常组（22.62 +/- 0.90）相比，可闭合角组的轴向长度（22.08 +/- 0.83）也有显著差异（p < 0.001）。PACG组的ACD和轴长分别为2.48 ± 0.22和22.02 ± 0.59。在调整年龄和性别的影响后，随着ACD（比值比，0.24; 95%置信区间，0.12-0.50）和轴长（比值比，0.49; 95%置信区间，0.36-0.67）每单位毫米的增加，可闭合角的风险降低。与正常组相比，患有可闭角型青光眼和闭角型青光眼的尼泊尔人群的眼睛似乎具有显著较浅的前房和较短的眼轴长度。（Optom维斯科学2011; 88：150-154）
Purpose. To compare the anterior chamber depth (ACD) and axial length of eyes in a population-based sample among normal, occludable angle, and primary angle-closure glaucoma (PACG) groups.Methods. Totally, 3979 subjects from a population-based glaucoma prevalence study underwent complete ocular examination including four mirror gonioscopy. An angle in which > 270 degrees of the posterior trabecular meshwork could not be seen was considered occludable. PACG was considered when there were features of primary angle closure (eye with an occludable angle, peripheral anterior synechiae, increased intraocular pressure, iris whorling, lens opacities, or excessive pigment deposition on the trabecular surface) and optic disc with glaucomatous damage. A handheld ultrasonic biometer was used to measure the ACD and the axial length of subjects. The ACD and axial length were measured on all subjects with occludable angles (n = 86), PACG (n = 17) and a random subgroup of normal subjects (n = 685). The measurements were compared among the groups and statistically analyzed using independent t-test, one-way analysis of variance, chi(2) test, and logistic regression.Results. The mean age among occludable angle and angle-closure glaucoma groups was 59.64 +/- 9.70 and 71.23 +/- 8.5 years, respectively, which was significantly higher (p < 0.001) than the mean of 54.03 +/- 10.90 years among normal subjects. In the occludable angle group, the ACD (2.55 +/- 0.69) was significantly different (p < 0.001) than the normal group (2.85 +/- 0.39). The axial length (22.08 +/- 0.83) in the occludable angle group was also considerably different (p < 0.001) when compared with the normal group (22.62 +/- 0.90). In PACG group, the ACD and axial length were 2.48 +/- 0.22 and 22.02 +/- 0.59, respectively. The risk of having an occludable angle decreased with per unit millimeter increase in ACD (odds ratio, 0.24; 95% confidence intervals, 0.12-0.50) and axial length (odds ratio, 0.49; 95% confidence intervals, 0.36-0.67) after adjusting the effect of age and sex.Conclusions. The eyes in Nepalese population with occludable angle and angle-closure glaucoma appear to have significantly shallower anterior chambers and shorter axial lengths when compared with the normal group. (Optom Vis Sci 2011; 88: 150-154)