RELATIONSHIP OF NICOTINAMIDE AND NICOTINIC ACID TO HYPOLIPIDEMIA
RELATIONSHIP OF NICOTINAMIDE AND NICOTINIC ACID TO HYPOLIPIDEMIA
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DOI：
10.1016/0006-2952(70)90011-0
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发表时间：
1970-01-01
影响因子：
5.8
通讯作者：
DWYER, JX
中科院分区：
文献类型：
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作者：
DALTON, C;VANTRABERT, TC;DWYER, JX
在禁食大鼠中，急性给予烟酰胺样烟酸导致血清胆固醇、甘油三酯和游离脂肪酸降低。然而，这些作用所需的烟酰胺剂量远大于烟酸。发现烟酰胺的血清半衰期是烟酸的三倍。烟酰胺的降血脂作用持续时间比烟酸长，烟酸在血清中的蓄积量与烟酰胺的注射剂量成正比。烟酰胺处理后血清中烟酸的浓度大于产生游离脂肪酸降低所需的最低血清浓度。可以得出结论，烟酰胺的减脂作用是间接的，并依赖于脱酰胺生成烟酸。
Acute administration of nicotinamide-like nicotinic acid caused a decrease of serum cholesterol, triglycerides and free-fatty acids in the fasted rat. However, the dose of nicotinamide required for these effects was much larger than that of nicotinic acid. The serum half-life of nicotinamide was found to be three times greater than nicotinic acid. The duration of hypolipidemic activity of nicotinamide was longer than that of nicotinic acid.Nicotinic acid was found to accumulate in the serum in amounts proportional to the injected dose of nicotinamide. The concentration of nicotinic acid in the serum after nicotinamide treatment was larger than minimal serum concentrations necessary to produce free-fatty acid lowering. It was concluded that the lipopenic action of nicotinamide was indirect and was dependent upon deamidation to nicotinic acid.