Twice‐daily dosing of valproate with divalproex
Twice‐daily dosing of valproate with divalproex
复制标题
丙戊酸与双丙戊酸每日两次给药
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
R. Perchalski
中科院分区：
文献类型：
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作者：
B. Wilder;B. Karas;E. Hammond;R. Perchalski
Equivalent doses of enteric‐coated divalproex were substituted for valproic acid in 15 epileptic patients who were on a three‐ or four‐times‐a‐day dosing schedule. After 2 wk the dosing regimen was changed to twice‐daily divalproex dosing, and plasma levels were determined during the 12‐hr period after the morning dose. Peak absorption was reached at 4 hr; extended plateaus were noted thereafter. The mean fluctuation between low and high plasma values for the group was 46%, with a decrease of less than 50% of peak levels in 9 of the 15 patients at a sampling time just before the second dose. Breakthrough seizures did not occur as a result of twice‐daily dosing.
