Efficacy and Tolerability of a Fixed-Dose Combination of Metoprolol Extended Release/Amlodipine in Patients with Mild-to-Moderate Hypertension A Randomized, Parallel-Group, Multicentre Comparison with Losartan plus Amlodipine
Efficacy and Tolerability of a Fixed-Dose Combination of Metoprolol Extended Release/Amlodipine in Patients with Mild-to-Moderate Hypertension A Randomized, Parallel-Group, Multicentre Comparison with Losartan plus Amlodipine
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DOI：
10.2165/11531770-000000000-00000
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
Gupta, Bhagwan S.
中科院分区：
文献类型：
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作者：
Pareek, Anil;Chandurkar, Nitin B.;Gupta, Bhagwan S.
背景：流行病学研究和临床试验表明，预防心血管疾病是高血压治疗的最终目标，需要充分降低血压。目的：本研究的主要目的是比较美托洛尔缓释(XL)/氨氯地平固定剂量联合与氯沙坦+氨氯地平联合治疗轻中度高血压患者的收缩压(SBP)和舒张压(DBP)的平均降幅。这项研究的次要目标是比较两个治疗组的应答者比例，并评估研究药物的耐受性。方法：这是一项在印度三家教学医院的门诊部进行的随机、平行分组、多中心比较研究。研究对象为年龄在18~75岁之间的轻中度高血压患者(DBP 90~109 mm Hg)，随访12周。根据SBP和DBP的平均下降和应答率(降低到SBP)来评估对研究治疗的反应
Background: Epidemiological studies and clinical trials have shown that prevention of cardiovascular disease, the ultimate goal of hypertension treatment, requires a sufficient reduction in blood pressure.Objective: The primary objective of this study was to compare the mean decrease in systolic (SBP) and diastolic (DBP) blood pressure between metoprolol extended release (XL)/amlodipine fixed-dose combination and losartan plus amlodipine combination in patients with mild-to-moderate essential hypertension. The secondary objectives of this study were to compare the proportion of responders in the two treatment groups and to evaluate the tolerability of the study medications.Methods: This was a randomized, parallel-group, multicentre comparative study conducted at the outpatient departments of three teaching hospitals in India. Patients with mild-to-moderate hypertension (defined as DBP 90-109 mmHg) aged between 18 and 75 years were enrolled in this study and followed up for 12 weeks. Response to study treatments was evaluated in terms of mean decrease in SBP and DBP and the response rate (reduction to SBP