A prospective study of bone loss in menopausal Australian-born women
A prospective study of bone loss in menopausal Australian-born women
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DOI：
10.1007/s001980050066
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发表时间：
1998-01-01
影响因子：
4
通讯作者：
Wark, JD
中科院分区：
文献类型：
--
作者：
Guthrie, JR;Ebeling, PR;Wark, JD
224 名女性（74 名绝经前、90 名围绝经期、60 名绝经后）。年龄在 46-59 岁之间的人群，来自参与一项骨矿物质密度 (BMD) 纵向研究的人群。通过双能 X 射线骨密度仪（DXA）测量腰椎和股骨颈的 BMD，骨扫描的时间间隔平均为 25（范围 14-41）个月。该研究的目的是评估骨密度的变化与正常绝经状态变化的关系。在研究期间，在第二次骨扫描时末次月经过去 3 至 1 个月之间的女性（n = 22，围绝经期晚期），腰椎 BMD 的平均（SE）年变化为 -0.9%（0.4%），股骨颈的 BMD 为 -0.7%（0.6%）（与仍处于绝经前的女性相比，p < 0.05）。在绝经后的女性 (n = 42) 中，腰椎 BMD 的平均年变化为 -2.5% (0.2%)，股骨颈的年平均变化为 -1.7% (0.2%)（均 p < 0.0005），而在绝经后的女性 (n = 60) 中，BMD 的年平均变化分别为 -0.7% (0.2%) 和 -0.5% (0.3%) 每年 （均 p < 0.05），与仍处于绝经前的女性相比。在末次月经 (FMP) 后 1-3 年内，腰椎骨质流失量大于股骨颈 (p < 0.05)。在第二次骨扫描时处于月经期且 FMP 可以前瞻性确定日期的女性 (n = 35) 中，较高的基线雌二醇水平与较少的腰椎骨质流失相关 (p < 0.005)。在绝经后的女性中，基线体重指数 (BMI) 与股骨颈 BMD 每年的变化百分比之间存在关联 (p
Two hundred and twenty-four women (74 pre-, 90 peri-, 60 post-menopausal). aged 46-59 years, from a population-based cohort participated in a longitudinal study of bone mineral density (BMD). BMD was measured by dual-energy X-ray absorptiometry (DXA) at the lumbar spine and femoral neck and the time between bone scans was on average 25 (range 14-41) months. The aim of the study was to assess changes in BMD in relation to changes in normal menopausal status. During the study period women who were between 3 and i' months past their last menstrual period (n = 22, late perimenopausal) at the time of the second bone scan had a mean (SE) annual change in BMD of -0.9% (0.4%) at the lumbar spine and -0.7% (0.6%) at the femoral neck (both p < 0.05 compared with women who remained premenopausal). In the women who became postmenopausal (n = 42) the mean annual changes in BMD were -2.5% (0.2%) at the lumbar spine and -1.7% (0.2%) at the femoral neck (both p < 0.0005), and in the women who remained postmenopausal (n = 60) they were -0.7% (0.2%) per year and -0.5% (0.3%) per year respectively (both p < 0.05), compared with women who remained premenopausal. In the 1-3 years after the final menstrual period (FMP) there was greater bone loss from the lumbar spine than the femoral neck (p < 0.05). In women who were menstruating at the time of the second bone scan and whose FMP could be dated prospectively (n = 35), higher baseline oestradiol levels were associated with less lumbar spine bone loss (p < 0.005). In the women who remained postmenopausal there was an association between baseline body mass index (BMI) and percentage change per year in femoral neck BMD (p