Comparison of oscillatory activity in subthalamic nucleus in Parkinson's disease and dystonia.
Comparison of oscillatory activity in subthalamic nucleus in Parkinson's disease and dystonia.
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帕金森病和肌张力障碍的丘脑底核振荡活动比较
DOI：
10.1016/j.nbd.2016.12.006
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发表时间：
2017-02
影响因子：
6.1
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Geng X;Zhang J;Jiang Y;Ashkan K;Foltynie T;Limousin P;Zrinzo L;Green A;Aziz T;Brown P;Wang S
深部脑刺激（DBS）的丘脑底核（STN）已成功地用于治疗帕金森病（PD）和肌张力障碍。PD患者STN记录的局部场电位（LFPs）显示出明显的β频带活动。目前尚不清楚这种活动是否发生在肌张力障碍的STN中，如果没有，肌张力障碍是否在STN中有另一种独特的神经群活动。12例PD患者和8例肌张力障碍患者接受了针对STN的DBS电极植入。7例肌张力障碍患者停药，1例服用阿立哌唑和氯硝西泮。用DBS电极记录PD在开/关药物状态和肌张力障碍状态下的lfp。比较了两种状态下lfp的功率谱和时间动态。在低频、β和高γ波段上，肌张力障碍关闭和PD开启/关闭以及PD关闭和PD开启之间的归一化功率谱和丘脑下lfp的Lempel-Ziv复杂性存在差异。肌张力障碍和停药患者的β功率较低，但低频和高伽马功率高于PD。在低β频率（11-20 Hz）范围内的频谱功率在药物PD中减弱。结果表明，肌张力障碍和PD即使在同一个核内也具有不同的振荡活动模式，而过度的β活动可能与低多巴胺能状态有关。
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been successfully used to treat both Parkinson's disease (PD) and dystonia. Local field potentials (LFPs) recorded from the STN of PD patients demonstrate prominent beta frequency band activity. It is unclear whether such activity occurs in the STN in dystonia, and, if not, whether dystonia has another distinctive neural population activity in the STN. Twelve patients with PD, and eight patients with dystonia underwent DBS electrode implantation targeting the STN. Seven dystonia patients were off medication and one was on aripiprazole and clonazepam. LFPs were recorded from the DBS electrodes in PD in the on/off medication states and in dystonia. Power spectra and temporal dynamics measured by the with Lempel-Ziv complexity of the LFPs were compared among these states. Normalised power spectra and Lempel-Ziv complexity of subthalamic LFPs differed between dystonia off and PD on/off, and between PD off and on over the low frequency, beta and high gamma bands. Patients with dystonia and off medication had lower beta power but higher low frequency and high gamma power than PD. Spectral power in the low beta frequency (11–20 Hz) range was attenuated in medicated PD. The results suggest that dystonia and PD are characterized by different patterns of oscillatory activities even within the same nucleus, and exaggerated beta activity may relate to hypo-dopaminergic status.