Co-delivery of paclitaxel and gemcitabine via a self-assembling nanoparticle for targeted treatment of breast cancer.
Co-delivery of paclitaxel and gemcitabine via a self-assembling nanoparticle for targeted treatment of breast cancer.
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通过自组装纳米颗粒共同递送紫杉醇和吉西他滨用于乳腺癌的靶向治疗
作者：
多功能纳米粒可用于提高抗肿瘤药物的治疗指数和减少副作用。本研究通过自组装技术制备了一种多功能、高生物相容性的叶酸（FA）、紫杉醇（PTX）和吉西他滨（GEM）纳米粒（NP）。透射电子显微镜（TEM）结果表明，多功能FA靶向纳米粒（MF-FA NPs）在水溶液中具有良好的结构稳定性和球形形貌。此外，与纯药物相比，NP（MF-FA NP和MF NP）对乳腺癌细胞4 T1表现出相当的增殖抑制。在体内抗肿瘤实验中，纳米粒的抗肿瘤活性明显高于纯药物。此外，由于FA特异性靶向癌细胞，MF-FA NPs显示出比MF NPs更高的肿瘤生长抑制。因此，新的MF-FA纳米颗粒可用作乳腺癌治疗的潜在化疗制剂。
Multi-functional nanoparticles can be used to improve the treatment index and reduce side effects of anti-tumor drugs. Herein, we developed a kind of multi-functional and highly biocompatible nanoparticle (NP) loaded with folic acid (FA), paclitaxel (PTX) and gemcitabine (GEM) via self-assembly to target cancer cells. The transmission electron microscopy (TEM) results showed that multi-functional FA targeting nanoparticles (MF-FA NPs) exhibited spherical morphology and favorable structural stability in aqueous solution. In addition, NPs (MF-FA NPs and MF NPs) exhibited comparable proliferation inhibition to breast cancer cell 4T1 compared with the pure drug. In in vivo antitumor studies, NPs showed an obviously enhanced anti-tumor efficacy compared with the pure drug. Furthermore, MF-FA NPs displayed higher tumor growth inhibition than MF NPs due to the specific targeting of FA to cancer cells. Consequently, the novel MF-FA NPs could be used as a potential chemotherapeutic formulation for breast cancer therapy.
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影响因子：
45.3
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