LdCompare:: rapid computation of single- and multiple-marker r2 and genetic coverage
LdCompare:: rapid computation of single- and multiple-marker r2 and genetic coverage
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DOI：
10.1093/bioinformatics/btl574
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发表时间：
2007-01-15
期刊：
影响因子：
5.8
通讯作者：
Cawley, S.
中科院分区：
文献类型：
--
作者：
Hao, K.;Di, X.;Cawley, S.
遗传变异数据集的规模已大大增加，这些多态性的连锁平衡（LD）结构，特别是在全基因组关联研究中，引起了人们极大的兴趣。在全基因组范围内计算单标记和多标记相关性的巨大计算复杂性仍然具有挑战性。我们开发了一个程序，可以根据单标记和多标记相关性有效地表征大量 SNP 的全基因组 LD 结构。
The scale of genetic-variation datasets has increased enormously and the linkage equilibrium (LD) structure of these polymorphisms, particularly in whole-genome association studies, is of great interest. The significant computational complexity of calculating single- and multiple-marker correlations at a genome-wide scale remains challenging. We have developed a program that efficiently characterizes whole-genome LD structure on large number of SNPs in terms of single- and multiple-marker correlations.