Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon
Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon
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DOI：
10.1128/jvi.01455-06
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发表时间：
2007-01-01
影响因子：
5.4
通讯作者：
Milligan, Gregg N.
中科院分区：
文献类型：
--
作者：
Bird, Melanie D.;Chu, Chin-Fun;Milligan, Gregg N.
从女性生殖道早期清除胸苷激酶缺陷型单纯疱疹病毒2型需要T细胞产生的γ干扰素（IFN-γ）。将活化的CD 8（+）T细胞转移到受辐射的C5713 L/6小鼠中导致病毒快速清除，但在IFN-γ受体（IFN-γ R）缺陷的受体中清除大大延迟。在IFN-γ R表达仅限于实质细胞的辐射嵌合体中证实了早期病毒清除，但在IFN-γ R表达缺陷的嵌合体和仅在造血细胞上表达IFN-γ R的嵌合体中，病毒清除显著延迟。总之，这些结果表明，早期IFN-γ介导的保护主要表现为生殖器实质细胞的刺激。
Early clearance of a thymidine kinase-deficient strain of herpes simplex virus type 2 from the female genital tract required T-cell-produced gamma interferon (IFN-gamma). Transfer of activated CD8(+) T cells to irradiated C5713L/6 mice resulted in rapid virus clearance, but clearance was greatly delayed in recipients deficient in the IFN-gamma receptor (IFN-gamma R). Early virus clearance was demonstrated in radiation chimeras in which IFN-gamma R expression was limited to parenchymal cells, but resolution was significantly delayed in chimeras deficient in IFN-gamma R expression and chimeras expressing IFN-gamma R only on bematopoietic cells. Together, these results suggest that early IFN-gamma-mediated protection was manifested mainly by stimulation of genital parenchymal cells.