IDENTIFIABILITY ANALYSIS AND PARAMETER-IDENTIFICATION OF AN INVIVO LIGAND-RECEPTOR MODEL FROM PET DATA
IDENTIFIABILITY ANALYSIS AND PARAMETER-IDENTIFICATION OF AN INVIVO LIGAND-RECEPTOR MODEL FROM PET DATA
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DOI：
10.1109/10.55673
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发表时间：
1990-07-01
影响因子：
4.6
通讯作者：
MAZOYER, BM
中科院分区：
文献类型：
--
作者：
DELFORGE, J;SYROTA, A;MAZOYER, BM
从单一示踪剂注射获得的数据中识别模型参数会导致令人失望的数值结果，因为大多数参数必须被认为是不可识别的。一种包括两次注射，第一次注射标记配体和第二次注射冷配体(置换实验)的方案，导致了两个非常不同的数值解，这是令人惊讶的，因为初步的理论可识别性研究并没有表明这种多解性。结果表明，三次注射方案，包括置换和共注射实验，使得确定这两种溶液中哪一种是生物有效的成为可能。
The identification of the model parameters from data obtained with a single tracer injection leads to disappointing numerical results, since most of the parameters have to be considered as unidentifiable. A protocol including two injections, a first injection of the labeled ligand and a second injection of the cold ligand (displacement experiment), leads to two very different numerical solutions, which is surprising, since such multiplicity of solutions was not indicated by a preliminary theoretical identifiability study. It is shown that a three-injections protocol, including both a displacement and a coinjection experiment, makes it possible to determine which of these two solutions is biologically valid.<>