Adiposity to muscle ratio predicts incident physical limitation in a cohort of 3,153 older adults-an alternative measurement of sarcopenia and sarcopenic obesity
Adiposity to muscle ratio predicts incident physical limitation in a cohort of 3,153 older adults-an alternative measurement of sarcopenia and sarcopenic obesity
复制标题
DOI：
10.1007/s11357-012-9423-9
复制
发表时间：
2013-08-01
期刊：
影响因子：
--
通讯作者：
Woo, Jean
中科院分区：
文献类型：
--
作者：
Auyeung, Tung Wai;Lee, Jenny Shun Wah;Woo, Jean
传统上，肌肉减少症是根据肌肉质量和身体表现来定义的。我们假设肌肉减少症和肌肉减少性肥胖引起的残疾与脂肪量或单位肌肉质量所承受的体重或脂肪与肌肉的比率有关。因此，我们通过对之前研究中的数据进行二次分析，检验了该比率是否可以预测身体限制。我们招募了 3,153 名年龄 > 65 岁的社区居民，并通过双能 X 射线吸收法测量了他们的身体成分。 4年后进行了身体限制评估。通过逻辑回归检查基线肥胖与肌肉比率和事件身体限制之间的关系。在男性中，肥胖与肌肉的比率，即全身脂肪与下肢肌肉质量、全身脂肪与去脂体重 (FFM) 以及体重与 FFM 的比例，在调整协变量之前和之后预测身体限制：年龄、简易精神状态检查评分、老年抑郁量表评分 > 8，以及慢性阻塞性肺病、糖尿病、高血压、心脏病和中风的诊断（所有 p 值 < 0.001），当全身脂肪与下肢肌肉质量之比大于或等于0.75时。在女性中，在该比率的整个范围内，所有三种肥胖与肌肉比率均与 4 年后的身体限制相关，无论是在调整同一组协变量之前还是之后（所有 p 值均 < 0.05）。通过体重或肌肉质量单位的肥胖（脂肪与肌肉的比率）来测量肌肉减少症和肌肉减少性肥胖，可以预测老年女性在全身脂肪与下肢肌肉质量比率的整个范围内发生或恶化的身体限制；在老年男性中，该比率等于或大于 0.75。
Conventionally, sarcopenia is defined by muscle mass and physical performance. We hypothesized that the disability caused by sarcopenia and sarcopenic obesity was related to the amount of adiposity or body weight bearing on a unit of muscle mass, or the adiposity to muscle ratio. We therefore examined whether this ratio could predict physical limitation by secondary analysis of the data in our previous study. We recruited 3,153 community-dwelling adults aged > 65 years and their body composition was measured by dual-energy X-ray absorptiometry. Assessment of physical limitation was undertaken 4 years later. The relationship between baseline adiposity to muscle ratio and incident physical limitation was examined by logistic regression. In men, the adiposity to muscle ratios, namely total body fat to lower-limb muscle mass, total body fat to fat-free mass (FFM), and body weight to FFM, were predictive of physical limitation before and after adjustment for the covariates: age, Mini-mental Status Examination score, Geriatric Depression Scale score > 8, and the diagnosis of chronic obstructive pulmonary disease, diabetes mellitus, hypertension, heart disease, and stroke (all p values < 0.001), when the total body fat to lower-limb muscle mass ratio was greater than or equal to 0.75. In women, throughout the entire range of that ratio, all three adiposity to muscle ratios were associated with physical limitation 4 years later both before and after adjustment for the same set of covariates (all p values < 0.05). Sarcopenia and sarcopenic obesity as measured by the body weight or adiposity bearing on a unit of muscle mass (the adiposity to muscle ratio) could predict incident or worsening physical limitation in older women across the entire range of the total body fat to lower-limb muscle mass ratio; and in older men when this ratio was equal to or greater than 0.75.