Bivariate linkage confirms genetic contribution to fetal origins of childhood growth and cardiovascular disease risk in Hispanic children
Bivariate linkage confirms genetic contribution to fetal origins of childhood growth and cardiovascular disease risk in Hispanic children
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DOI：
10.1007/s00439-007-0366-7
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发表时间：
2007-07-01
期刊：
影响因子：
5.3
通讯作者：
Comuzzie, Anthony G.
中科院分区：
文献类型：
--
作者：
Cai, Guowen;Cole, Shelley A.;Comuzzie, Anthony G.
出生体重已经被证明与成年后的肥胖和代谢性疾病有关，然而，遗传因素仍然存在争议。这项分析的目的是探索西班牙裔儿童出生体重与日后肥胖和代谢性疾病风险之间的关系的遗传贡献。研究对象为1,030名西班牙裔儿童，研究对象为家庭万岁。表型包括身体大小、身体成分、血压、空腹血糖、胰岛素、血脂和肝酶。出生体重是从德克萨斯州的出生证明中获得的。使用SOLAR软件进行定量遗传分析。出生体重是高度可遗传的，所有其他表型也是如此。从表型上看，出生体重与儿童时期的体型参数呈正相关。将这些表型相关分解为遗传和环境成分，显示出显著的遗传相关性，范围在0.30到0.59之间。出生体重与血脂呈负遗传相关。出生体重的基因组扫描定位于标记D10S537(LOD=2.6)附近的区域。对出生体重和儿童体重或总胆固醇进行双变量全基因组扫描后，LOD得分分别提高到3.09和2.85。染色体10q22含有影响西班牙裔儿童出生体重和儿童体型以及心血管疾病风险的基因。
Birth weight has been shown to be associated with obesity and metabolic diseases in adulthood, however, the genetic contribution is still controversial. The objective of this analysis is to explore the genetic contribution to the relationship between birth weight and later risk for obesity and metabolic diseases in Hispanic children. Subjects were 1,030 Hispanic children in the Viva La Familia Study. Phenotypes included body size, body composition, blood pressure, fasting glucose, insulin, lipids, and liver enzymes. Birth weights were obtained from Texas birth certificates. Quantitative genetic analyses were conducted using SOLAR software. Birth weight was highly heritable, as were all other phenotypes. Phenotypically, birth weight was positively correlated to childhood body size parameters. Decomposition of these phenotypic correlations into genetic and environmental components revealed significant genetic correlations, ranging from 0.30 to 0.59. Negative genetic correlations were seen between birth weight and lipids. The genome scan of birth weight mapped to a region near marker D10S537 (LOD = 2.6). The bivariate genome-wide scan of birth weight and childhood weight or total cholesterol, improved the LOD score to 3.09 and 2.85, respectively. Chromosome 10q22 harbors genes influencing both birth weight and childhood body size and cardiovascular disease risk in Hispanic children.