Failure of rat and rabbit antiserum to passively sensitize normal and pertussis-treated rats and mice so as to induce mast cell damage and histamine release on later contact with antigen.
Failure of rat and rabbit antiserum to passively sensitize normal and pertussis-treated rats and mice so as to induce mast cell damage and histamine release on later contact with antigen.
复制标题
大鼠和兔抗血清未能被动致敏正常和百日咳治疗的大鼠和小鼠，从而在随后与抗原接触时诱导肥大细胞损伤和组胺释放。
作者：
I. Mota
观察到，大鼠和小鼠的被动过敏反应不伴有肥大细胞损伤或组胺释放，也不重复这些物种的主动过敏反应的全部情况。此外，百日咳博德泰拉预处理虽然在大鼠和小鼠的主动过敏反应中增强肥大细胞损伤和组胺释放，但在被动过敏反应中不会诱导这些现象。还观察到，在大鼠和小鼠中注射可溶性抗原抗体复合物也不会重现活动性过敏反应中发现的肥大细胞损伤和组胺释放。
It was observed that passive anaphylaxis in rats and mice is not accompanied by mast cell damage or histamine release and does not duplicate the full picture of active anaphylaxis in these species. Furthermore, pretreatment with Bordetella pertussis although enhancing mast cell damage and histamine release in active anaphylaxis of rats and mice does not induce these phenomena in passive anaphylaxis. It was also observed that injection of soluble antigen-antibody complexes in rats and mice also do not reproduce the mast cell damage and histamine release found in active anaphylaxis.
It is suggested that the mast cell damage and histamine release in active anaphylaxis of rats and mice is due to non-precipitating antibodies of an unknown nature and that anaphylaxis in passively sensitized rats and mice is the consequence of interaction of antigen with precipitating antibodies which do not lead to mast cell damage or histamine release in these species. It is also suggested that in active sensitization of rats and mice B. pertussis acts by stimulating the production of antibodies that are very efficient in inducing mast cell lysis on reaction with antigen. The possible role of soluble antigen-antibody complexes in passive anaphylaxis of these species is considered.