Enhancing the effectiveness of smoking treatment research: conceptual bases and progress
Enhancing the effectiveness of smoking treatment research: conceptual bases and progress
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DOI：
10.1111/add.13154
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发表时间：
2016-01-01
期刊：
影响因子：
6
通讯作者：
Fiore, Michael C.
中科院分区：
文献类型：
--
作者：
Baker, Timothy B.;Collins, Linda M.;Fiore, Michael C.
背景和目的慢性病护理策略可以通过为所有吸烟者（包括最初不愿意戒烟的吸烟者）提供有效的干预措施，潜在地提高吸烟治疗的范围和有效性。本文介绍了美国国家癌症研究所资助的一项研究计划的概念基础，该计划旨在开发一种优化的、全面的、慢性护理吸烟治疗方法。方法本研究以三种方法论方法为基础：（1）基于阶段的模型，该模型指导选择干预成分，对吸烟治疗的不同阶段进行实验评估（2）多阶段优化策略（MOST），通过有效的实验设计指导干预成分的筛选，并最终将有希望的成分组合成优化的治疗方案;以及（3）实用的研究方法，如电子健康记录招募，促进研究结果有效地转化为临床实践。利用这一基础，并在初级保健诊所工作，我们进行了三个析因实验（在三篇随附论文中报告）筛选15个动机，准备，戒烟和维持阶段的干预组成部分，可能包括在慢性护理吸烟治疗计划。结果这项研究确定了干预组成部分，在特定阶段的吸烟治疗的有效性相对较强的证据，它表明，效率的MOST的方法在两个方面的干预组件测试和丰富的信息givened.ConclusionsA新的，综合的研究方法有效地评估多个干预组件，以确定有前途的组件吸烟治疗的每一个阶段。许多干预成分相互作用，支持在吸烟治疗开发中使用析因实验。
Background and aimsA chronic care strategy could potentially enhance the reach and effectiveness of smoking treatment by providing effective interventions for all smokers, including those who are initially unwilling to quit. This paper describes the conceptual bases of a National Cancer Institute-funded research program designed to develop an optimized, comprehensive, chronic care smoking treatment.MethodsThis research is grounded in three methodological approaches: (1) the Phase-Based Model, which guides the selection of intervention components to be experimentally evaluated for the different phases of smoking treatment (motivation, preparation, cessation, and maintenance); (2) the Multiphase Optimization Strategy (MOST), which guides the screening of intervention components via efficient experimental designs and, ultimately, the assembly of promising components into an optimized treatment package; and (3) pragmatic research methods, such as electronic health record recruitment, that facilitate the efficient translation of research findings into clinical practice. Using this foundation and working in primary care clinics, we conducted three factorial experiments (reported in three accompanying papers) to screen 15 motivation, preparation, cessation and maintenance phase intervention components for possible inclusion in a chronic care smoking treatment program.ResultsThis research identified intervention components with relatively strong evidence of effectiveness at particular phases of smoking treatment and it demonstrated the efficiency of the MOST approach in terms both of the number of intervention components tested and of the richness of the information yielded.ConclusionsA new, synthesized research approach efficiently evaluates multiple intervention components to identify promising components for every phase of smoking treatment. Many intervention components interact with one another, supporting the use of factorial experiments in smoking treatment development.