Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans
Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans
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DOI：
10.1210/jc.2007-2702
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发表时间：
2008-09-01
影响因子：
5.8
通讯作者：
Norris, Jill M.
中科院分区：
文献类型：
--
作者：
Engelman, Corinne D.;Fingerlin, Tasha E.;Norris, Jill M.
内容：维生素D缺乏症与许多不良的健康后果有关，但对维生素D或其代谢产物的遗传流行病学知之甚少。目的：我们的目的是检查三种维生素D相关基因与25-羟基维生素D [ 25（OH）D]和1，25-二羟基维生素D水平之间的关系[1，设计和设置：横断面胰岛素抵抗动脉粥样硬化家族研究，在洛杉矶，加州招募和检查受试者（AAs;来自42个家庭的513个个体）;圣路易斯谷（SLV），科罗拉多（HAs;来自30个家庭的513个个体）;和德克萨斯州的圣安东尼奥（SA）主要结果：测定血浆25（OH）D和1，25（OH）（2）D水平。结果：SLV-HA中25（OH）D水平最高[18.3 +/- 7.7 ng/ml（45.7 +/- 19.2 nmol/L）]，SA-HA较低[14.6 +/- 6.4 ng/ml（36.4 +/- 16.0 nmol/L）]，AA最低[11.0 +/- 5.4 ng/ml（27.5 +/- 13.5 nmol/L）]。AA中1，25（OH）（2）D的水平相似[43.5 +/- 13.9 pg/ml（113.1 +/- 36.1 pmol/L）]和SLV-HA [43.2 +/- 13.3 pg/ml（112.3 +/- 34.6 pmol/L）]，但在SA-HA中更高[48.6 +/- 17.0 pg/ml（126.4 +/- 44.2 pmol/L）]。在对研究中心内的性别和年龄进行调整后，在所有三个研究中心，维生素D结合蛋白基因（DBP）中的两个单核苷酸多态性（SNP）rs 4588和rs7041与25（OH）D相关，DBP中的一个SNP rs 4588与1，25（OH）（2）D相关。在胰岛素抵抗性动脉粥样硬化家族研究中，DBP中的SNP与HA和AA参与者的25（OH）D和1，25（OH）（2）D水平相关。
Context: Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites.Objective: Our objective was to examine the relationship among three vitamin D-related genes and levels of 25-hydroxyvitamin D [ 25( OH) D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] in Hispanics (HAs) and African Americans (AAs).Design and Setting: The cross-sectional Insulin Resistance Atherosclerosis Family Study recruited and examined subjects in: Los Angeles, California ( AAs; 513 individuals from 42 families); San Luis Valley (SLV), Colorado ( HAs; 513 individuals from 30 families); and San Antonio ( SA), Texas ( HAs; 504 individuals from 58 families).Main Outcome Measures: Plasma levels of 25( OH) D and 1,25( OH)(2)D were measured.Results: Levels of 25( OH) D were highest in SLV-HAs [18.3 +/- 7.7 ng/ml ( 45.7 +/- 19.2 nmol/liter)], lower in SA-HAs [14.6 +/- 6.4 ng/ml ( 36.4 +/- 16.0 nmol/liter)], and lowest in AAs [11.0 +/- 5.4 ng/ml (27.5 +/- 13.5 nmol/liter)]. Levels of 1,25( OH)(2)D were similar in AAs [43.5 +/- 13.9 pg/ml (113.1 +/- 36.1 pmol/liter)] and SLV-HAs [43.2 +/- 13.3 pg/ml (112.3 +/- 34.6 pmol/liter)], but higher in SA-HAs [48.6 +/- 17.0 pg/ml (126.4 +/- 44.2 pmol/liter)]. After adjusting for gender and age within the site, two single nucleotide polymorphisms ( SNPs) in the vitamin D binding protein gene (DBP), rs4588 and rs7041, were associated with 25(OH) D, and one SNP in the DBP, rs4588, was associated with 1,25(OH)(2)D at all three study centers.Conclusions: SNPs in the DBP are associated with levels of 25(OH) D and 1,25(OH)(2)D in HA and AA participants in the Insulin Resistance Atherosclerosis Family Study.