STIMULATION OF HUMAN FETAL ASTROCYTE PROLIFERATION BY BACTERIAL LIPOPOLYSACCHARIDES AND LIPID-A
STIMULATION OF HUMAN FETAL ASTROCYTE PROLIFERATION BY BACTERIAL LIPOPOLYSACCHARIDES AND LIPID-A
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DOI：
10.1007/bf00296549
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发表时间：
1991-01-01
影响因子：
12.7
通讯作者：
HERZ, F
中科院分区：
文献类型：
--
作者：
KATO, M;OHNO, K;HERZ, F
本报告关注细菌内毒素[脂多糖（LPS）和脂质A]对培养的人胎儿星形胶质细胞的影响。暴露于1 μ g/ml LPS或脂质A对细胞增殖率有显著的刺激作用。这种效应在呈指数增长的培养基中最为明显。刺激与[H-3]胸苷结合确定的DNA合成增强有关。这些在细胞水平上的发现可能与阐明细菌内毒素对发育中的人脑的影响有关。
This report concerns the effect of bacterial endotoxin [lipopolysaccharide(LPS) and lipid A] on cultured human fetal astrocytes. Exposure to 1-mu-g/ml LPS or lipid A caused a striking stimulation of the rate of proliferation of the cells. The effect was most pronounced with exponentially growing cultures. Stimulation was associated with enhance DNA synthesis as ascertained by [H-3]thymidine incorporation.These findings at the cellular level may be of relevance in the elucidation of the effects of bacterial endotoxins on the developing human brain.