The effect of a multidimensional exercise intervention on physical capacity, well-being and quality of life in cancer patients undergoing chemotherapy
The effect of a multidimensional exercise intervention on physical capacity, well-being and quality of life in cancer patients undergoing chemotherapy
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DOI：
10.1007/s00520-005-0864-x
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发表时间：
2006-02-01
影响因子：
3.1
通讯作者：
Rorth, M
中科院分区：
文献类型：
--
作者：
Adamsen, L;Quist, M;Rorth, M
本研究的目的是调查以身体能力为重点的多维运动干预的影响；接受化疗的癌症患者的单次最大摄氧量 (1RM) 和最大摄氧量 (VO(2)Max)、活动水平、总体健康状况和生活质量。干预措施包括阻力和健身训练、按摩、放松和身体意识训练。包括 82 名有或没有残留疾病证据的癌症患者：66 名患者患有 13 种不同类型的实体瘤，16 名患者患有 6 种类型的血液恶性肿瘤。患者在混合组中每周训练 9 小时，持续 6 周。在干预前后评估了通过医疗结果研究 36 项简短健康调查和欧洲癌症研究与治疗组织生活质量问卷 C30 测量的身体能力、身体活动水平和社会心理健康状况。肌肉力量 (p < 0.001)、体能 (p < 0.001) 和身体活动水平 (p < 0.001) 均实现了高度显着的增加。患者报告治疗相关症状显着减轻，即疲劳（p=0.006）和疼痛（p=0.03）。在身体功能 (p < 0.001) 和角色功能 (p < 0.001) 方面观察到非常显着的改善。即使患有晚期疾病的患者也能够在 6 周后改善其结果。结论是，包括阻力训练在内的多维运动干预可能对接受化疗的癌症患者有益。这项研究表明显着的临床意义的改善。干预措施的确切作用必须在随机对照设计中定义。目前正在进行一项包括 250 名患者的临床对照试验。
The aim of the present study was to investigate the impact of a multidimensional exercise intervention focusing on physical capacity; one-repetition maximum (1RM) and maximum oxygen uptake (VO(2)Max), activity level, general well-being and quality of life in cancer patients undergoing chemotherapy. The intervention comprised resistance and fitness training, massage, relaxation and body-awareness training. Eighty-two cancer patients, with or without evidence of residual disease, were included: 66 patients with 13 different types of solid tumours and 16 patients with 6 types of haematological malignancies. The patients trained in mixed groups for 9 h weekly for 6 weeks. Physical capacity, physical activity level and psychosocial well-being as measured by the Medical Outcomes Study 36-item Short-Form Health Survey and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 were assessed pre- and post-intervention. Highly significant increases were achieved in muscular strength (p < 0.001), physical fitness (p < 0.001) and physical activity levels (p < 0.001). The patients reported significant reduction in treatment-related symptoms, i.e., fatigue (p=0.006) and pain (p=0.03). Highly significant improvements were observed in physical functioning (p < 0.001) and role functioning (p < 0.001). Even patients with advanced disease were able to improve their results after 6 weeks. It is concluded that a multidimensional exercise intervention, including resistance training, may be beneficial for cancer patients undergoing chemotherapy. This study indicates significant clinical meaningful improvements. The exact role of the intervention has to be defined in a randomized controlled design. A clinically controlled trial including 250 patients is currently being carried out.