The prevalence of obesity and obesity-related health conditions in a large, multiethnic cohort of young adults in California
The prevalence of obesity and obesity-related health conditions in a large, multiethnic cohort of young adults in California
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DOI：
10.1016/j.annepidem.2012.05.006
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发表时间：
2012-09-01
影响因子：
5.6
通讯作者：
Kushi, Lawrence H.
中科院分区：
文献类型：
--
作者：
Koebnick, Corinna;Smith, Ning;Kushi, Lawrence H.
目的：确定最容易在年轻时出现肥胖相关健康状况的人群。方法：在这项以人群为基础的横断面研究中，从2007年至2009年加利福尼亚州两个综合健康计划中登记的1819,205名年龄在20至39岁之间的患者的电子病历中提取了测量的体重和身高、诊断、实验室和药物处方信息。结果：总体而言，29.9%的年轻人肥胖。极度肥胖（体重指数[BM] >= 40 kg/m(2)）在6.1%的女性和4.5%的男性中被观察到。BMI≥40时，糖尿病、高血压、血脂异常和代谢综合征的调整相对危险度（RR）急剧升高，其中高血压和代谢综合征的调整相对危险度（RR）升高幅度最大。与30.0 ~ 39.9岁的儿童相比，体重等级与血脂异常、高血压和代谢综合征（非糖尿病）之间的关联在20.0 ~ 29.9岁的儿童中更强（相互作用P < 0.05）。例如，与同龄体重正常的年轻人相比，BMI在40.0 ~ 49.9、50.0 ~ 59.9和60或更高kg/m2的年轻人在20 ~ 29岁时高血压的RR分别为11.73、19.88和30.47(95%可信区间[CI]， 26.39 ~ 35.17)，在30 ~ 39岁时高血压的RR分别为9.31、12.41和15.43 （95% CI, 14.32 ~ 16.63）。结论：尽管老年人更有可能极度肥胖，但肥胖相关健康状况之间的关联在年轻人中更强。西班牙裔和黑人也更容易肥胖，包括极度肥胖，与非西班牙裔白人相比，他们患过早心血管疾病和某些癌症的风险更高。(C) 2012爱思唯尔公司版权所有。
Purpose: To identify population groups that are most susceptible to obesity-related health conditions at young age.Methods: For this population-based cross-sectional study, measured weight and height, diagnosis, laboratory, and drug prescription information were extracted from electronic medical records of 1,819,205 patients aged 20 to 39 years enrolled in two integrated health plans in California in 2007 through 2009.Results: Overall, 29.9% of young adults were obese. Extreme obesity (body mass index [BM] >= 40 kg/m(2)) was observed in 6.1% of women and 4.5% of men. The adjusted relative risk (RR) for diabetes, hypertension, dyslipidemia, and the metabolic syndrome increased sharply for those individuals with a BMI of 40 or greater, with the sharpest increase in the adjusted RR for hypertension and the metabolic syndrome. The association between weight class and dyslipidemia, hypertension, and the metabolic syndrome but not diabetes was stronger among 20.0- to 29.9-year-olds compared with 30.0- to 39.9-year-olds (P for interaction < .05). For example, compared with their normal weight counterparts of the same age group, young adults with a BMI of 40.0 to 49.9, 50.0 to 59.9, and 60 or greater kg/m2 had a RR for hypertension of 11.73, 19.88, and 30.47 (95% confidence interval [CI], 26.39-35.17) at 20 to 29 years old, and 9.31, 12.41, and 15.43 (95% CI, 14.32-16.63) at 30 to 39 years old.Conclusions: Although older individuals were more likely to be extremely obese, the association between obesity-related health conditions was stronger in younger individuals. Hispanics and Blacks are also more likely to be obese, including extremely obese, putting them at an elevated risk for premature cardiovascular disease and some cancers relative to non-Hispanic Whites. (C) 2012 Elsevier Inc. All rights reserved.