The chronic mild stress (CMS) model of depression: History, evaluation and usage.
The chronic mild stress (CMS) model of depression: History, evaluation and usage.
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DOI：
10.1016/j.ynstr.2016.08.002
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发表时间：
2017-02
影响因子：
5
通讯作者：
Willner P
中科院分区：
文献类型：
--
作者：
Willner P
抑郁症的慢性轻度应激（CMS）模型已有 30 岁的历史，已被用于超过 1300 篇已发表的研究，同比增长到 2015 年达到超过 200 篇论文。来自用户调查的数据显示，虽然使用了多种名称（慢性轻度/不可预测/变化的压力），但这些名称基本上描述了相同的过程。本文提供了 CMS 模型有效性和可靠性的更新，并回顾了 CMS 效应的神经生物学基础和抗抑郁作用机制的最新数据：这项研究的数量可能是独一无二的，在单一模型中提供了抗抑郁作用的全面说明。还讨论了 CMS 在药物发现中的应用，特别是海马和海马外靶点。 CMS 模型的高转化潜力意味着所描述的神经生物学机制可能与人类抑郁症和临床抗抑郁作用机制特别相关。
Now 30 years old, the chronic mild stress (CMS) model of depression has been used in >1300 published studies, with a year-on-year increase rising to >200 papers in 2015. Data from a survey of users show that while a variety of names are in use (chronic mild/unpredictable/varied stress), these describe essentially the same procedure. This paper provides an update on the validity and reliability of the CMS model, and reviews recent data on the neurobiological basis of CMS effects and the mechanisms of antidepressant action: the volume of this research may be unique in providing a comprehensive account of antidepressant action within a single model. Also discussed is the use of CMS in drug discovery, with particular reference to hippocampal and extra-hippocampal targets. The high translational potential of the CMS model means that the neurobiological mechanisms described may be of particular relevance to human depression and mechanisms of clinical antidepressant action.