Impact of Systolic and Diastolic Deformation Indexes Assessed by Strain-Encoded Imaging to Predict Persistent Severe Myocardial Dysfunction in Patients After Acute Myocardial Infarction at Follow-Up
Impact of Systolic and Diastolic Deformation Indexes Assessed by Strain-Encoded Imaging to Predict Persistent Severe Myocardial Dysfunction in Patients After Acute Myocardial Infarction at Follow-Up
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DOI：
10.1016/j.jacc.2010.02.070
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发表时间：
2010-09-21
影响因子：
24
通讯作者：
Steen, Henning
中科院分区：
文献类型：
--
作者：
Neizel, Mirja;Korosoglou, Grigorios;Steen, Henning
目的：本研究评估应变编码成像测定的收缩和舒张变形指标在预测再灌注急性心肌梗死（AMI）患者随访时持续严重功能障碍方面的价值，并与晚期钆增强（LGE）进行比较。动物研究表明，局部舒张功能提供了AMI后心肌活力的信息。然而，人类的数据很少。方法26例st段抬高型心肌梗死再灌注成功后3 +/- 1天行磁共振成像，随访6个月。获取Cine、strain encoded和LGE图像。计算基线和随访时各节段的峰值收缩周应变（E(cc)）和早期舒张应变率（E(cc)/s）。截止E（cc）值为-9%用于定义随访时严重功能障碍。结果共分析312个节段；119段基线功能异常。随访时35节段出现严重功能障碍，随访时定义为Ecc
Objectives This study evaluated the value of systolic and diastolic deformation indexes determined by strain-encoded imaging to predict persistent severe dysfunction at follow-up in patients after reperfused acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE).Background Animal studies suggest that regional diastolic function provides information about myocardial viability after AMI. However, data in humans are sparse.Methods Twenty-six patients underwent magnetic resonance imaging 3 +/- 1 days after successfully reperfused ST-segment elevation myocardial infarction and at a follow-up of 6 months. Cine, strain-encoded, and LGE images were acquired. Peak systolic circumferential strain (E(cc)) and early diastolic strain rate (E(cc)/s) were calculated for each segment at baseline and at follow-up. A cutoff E(cc) value of -9% was used to define severe dysfunction at follow-up.Results A total of 312 segments were analyzed; 119 segments showed abnormal baseline function. Thirty-five segments showed severe dysfunction at follow-up, which was defined as Ecc at follow-up