Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China
Population structure and linkage disequilibrium of a mini core set of maize inbred lines in China
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DOI：
10.1007/s00122-008-0852-x
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发表时间：
2008-11-01
影响因子：
5.4
通讯作者：
Li, Yu
中科院分区：
文献类型：
--
作者：
Wang, Ronghuan;Yu, Yongtao;Li, Yu
了解目标群体的遗传多样性、群体结构以及连锁不平衡（LD）的水平和分布是关联作图的前提和重要内容。本研究利用145个SSR标记对95个代表中国玉米自交系的遗传多样性、群体结构和LD进行了分析。结果表明，该群体具有多样的遗传变异。基于模型的群体结构分析将自交系细分为四个亚组，对应于中国四个主要的经验种质来源，即，兰开斯特、Reid、Tangsippingtou和P.在所有的自交系中，65.3%的自交系属于相应的亚群，其余的自交系属于“混合”亚群。LD在整个样本中的63.89%的SSR对之间达到0.01的显著水平，在亚组中的范围为18.75-40.28%。在影响LD的因素中，连锁是导致SSR位点LD的主要原因。结果表明，该群体可用于全基因组SSR标记-表型关联的检测。
Understanding genetic diversity, population structure, and the level and distribution of linkage disequilibrium (LD) in target populations are of great importance and the prerequisite for association mapping. In the present study, 145 genome-wide SSR markers were used to assess the genetic diversity, population structure, and LD of a set of 95 maize inbred lines which represented the Chinese maize inbred lines. Results showed that the population included a diverse genetic variation. A model-based population structure analysis subdivided the inbred lines into four subgroups that correspond to the four major empirical germplasm origins in China, i.e., Lancaster, Reid, Tangsipingtou and P. Among all of the inbred lines, 65.3% were assigned into the corresponding subgroups; others were assigned into a "mixed" subgroup. LD was significant at a 0.01 level between 63.89% of the SSR pairs in the entire sample and with a range of 18.75-40.28% in the subgroups. Among factors influencing LD, linkage was the major cause for LD of SSR loci. The results suggested that the population may be used in the detection of genome-wide SSR marker-phenotype association.