A neurochemical description of the dopaminergic innervation of the stomatogastric ganglion of the spiny lobster.
A neurochemical description of the dopaminergic innervation of the stomatogastric ganglion of the spiny lobster.
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大龙虾口胃神经节多巴胺能神经支配的神经化学描述。
DOI：
10.1002/neu.480140104
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Barker,DL
中科院分区：
文献类型：
--
作者：
Kushner,PD;Barker,DL
大龙虾口胃神经节已被证明受到源自大中央神经节细胞的儿茶酚胺能过程的神经支配（Kushner 和 Maynard，1977）。生化证据表明，口胃系统从氚化酪氨酸合成多巴胺而不是去甲肾上腺素（Barker、Kushner 和 Hooper，1979）。这里报告的研究表明，通过敏感的内源性测定法测量，口胃神经节本身含有多巴胺。此外，神经节可以从氚化酪氨酸或多巴合成多巴胺。此外，当在氚化多巴胺中孵育时，神经节会吸收多巴胺并保护其免遭降解。可卡因会抑制这一过程。当与3H-酪氨酸一起孵育时，在神经节周围的介质中检测到少量但可测量的氚化多巴胺。
The spiny lobster stomatogastric ganglion has been shown to be innervated by catecholaminergic processes which derive from cells of large central ganglia (Kushner and Maynard, 1977). Biochemical evidence had indicated that the stomatogastric system synthesizes dopamine and not norepinephrine from tritiated tyrosine (Barker, Kushner, and Hooper, 1979). Studies reported here document that the stomatogastric ganglion itself contains dopamine, as measured with a sensitive endogenous assay. Moreover, the ganglion can synthesize dopamine from tritiated tyrosine or DOPA. Additionally, when incubated in tritiated dopamine, the ganglion takes up dopamine and protects it from degradation; this process is inhibited by cocaine. When incubated with3H‐tyrosine, small but measurable amounts of tritiated dopamine were detected in the medium surrounding the ganglion.